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Analysis of Non-linear Pharmacokinetics of P-Glycoprotein Substrates in a Microfluidic Device Using a Mathematical Model that Includes an Unstirred Water Layer (UWL) Compartment.
Igarashi, Fumihiko; Nakagawa, Toshito; Shinohara, Yuka; Tachibana, Tatsuhiko.
Affiliation
  • Igarashi F; Discovery ADMET Department, Research Division, Chugai Pharmaceutical Co., Ltd, Gotemba, Shizuoka, Japan. igarashi.fumihiko07@chugai-pharm.co.jp.
  • Nakagawa T; Discovery ADMET Department, Research Division, Chugai Pharmaceutical Co., Ltd, Gotemba, Shizuoka, Japan.
  • Shinohara Y; Discovery ADMET Department, Research Division, Chugai Pharmaceutical Co., Ltd, Gotemba, Shizuoka, Japan.
  • Tachibana T; Discovery ADMET Department, Research Division, Chugai Pharmaceutical Co., Ltd, Gotemba, Shizuoka, Japan.
Pharm Res ; 38(6): 1031-1039, 2021 Jun.
Article in En | MEDLINE | ID: mdl-34009624
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Water / Nonlinear Dynamics / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Lab-On-A-Chip Devices / Models, Theoretical Type of study: Prognostic_studies Limits: Humans Language: En Journal: Pharm Res Year: 2021 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Water / Nonlinear Dynamics / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Lab-On-A-Chip Devices / Models, Theoretical Type of study: Prognostic_studies Limits: Humans Language: En Journal: Pharm Res Year: 2021 Document type: Article Affiliation country: Country of publication: