A tale of four studies: HIV vaccine immunogenicity and efficacy in clinical trials.
Lancet HIV
; 8(7): e449-e452, 2021 07.
Article
in En
| MEDLINE
| ID: mdl-34029515
ABSTRACT
The advanced-phase HIV prevention vaccine trials done in South Africa (HVTN 702) and in Thailand (RV144), which both investigated canarypox vectors and adjuvanted gp120 proteins, gave rise to different results. The South African trial did not find vaccine efficacy, whereas the Thai trial had modest, but statistically significant, success with the modified intention-to-treat analysis prespecified in the protocols of both studies. An understanding of the differences between the studies is required to avoid the possible, but erroneous, conclusion that the results from the South African trial negatively affect the results of the Thai trial.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
HIV Infections
/
HIV-1
/
AIDS Vaccines
Type of study:
Clinical_trials
Limits:
Humans
Country/Region as subject:
Africa
/
Asia
Language:
En
Journal:
Lancet HIV
Year:
2021
Document type:
Article