Rapid resolution of choroidal metastatic tumour secondary to lung cancer following treatment with alectinib.
BMJ Case Rep
; 14(5)2021 May 24.
Article
in En
| MEDLINE
| ID: mdl-34031063
ABSTRACT
A 64-year-old man presented with reduced vision in the right eye (visual acuity of 6/24 Snellen). The patient reported having a chronic cough and recent weight loss with difficulty in swallowing and abnormal liver function test 8 months prior to his presentation. He was a chronic smoker for 45 years, having quit a year earlier. Fundus examination showed a unifocal large yellow-brown subretinal mass involving the posterior segment of the eye and associated with subretinal fluid. The patient was diagnosed with a choroidal metastasis and was referred urgently to the oncology team who confirmed the presence of non-small cell lung cancer with distant metastases. He started treatment with alectinib (second-generation tyrosine kinase inhibitor). A few weeks later, his vision improved and, on examination, there was complete resolution of the choroidal mass and the associated subretinal fluid. Alectinib led to rapid resolution of his choroidal secondary and has excellent ocular safety profile.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Choroid Neoplasms
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Carcinoma, Non-Small-Cell Lung
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Lung Neoplasms
Limits:
Humans
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Male
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Middle aged
Language:
En
Journal:
BMJ Case Rep
Year:
2021
Document type:
Article
Affiliation country: