The liver-clock coordinates rhythmicity of peripheral tissues in response to feeding.
Nat Metab
; 3(6): 829-842, 2021 06.
Article
in En
| MEDLINE
| ID: mdl-34059820
ABSTRACT
The mammalian circadian system consists of a central clock in the brain that synchronizes clocks in the peripheral tissues. Although the hierarchy between central and peripheral clocks is established, little is known regarding the specificity and functional organization of peripheral clocks. Here, we employ altered feeding paradigms in conjunction with liver-clock mutant mice to map disparities and interactions between peripheral rhythms. We find that peripheral clocks largely differ in their responses to feeding time. Disruption of the liver-clock, despite its prominent role in nutrient processing, does not affect the rhythmicity of clocks in other peripheral tissues. Yet, unexpectedly, liver-clock disruption strongly modulates the transcriptional rhythmicity of peripheral tissues, primarily on daytime feeding. Concomitantly, liver-clock mutant mice exhibit impaired glucose and lipid homeostasis, which are aggravated by daytime feeding. Overall, our findings suggest that, upon nutrient challenge, the liver-clock buffers the effect of feeding-related signals on rhythmicity of peripheral tissues, irrespective of their clocks.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Energy Intake
/
Circadian Rhythm
/
Circadian Clocks
/
Liver
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Nat Metab
Year:
2021
Document type:
Article
Affiliation country: