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Prognostic Significance of HER2 Expression for Gastric Cancer With Clinically Para-aortic Lymph Node Metastasis.
Arigami, Takaaki; Matsushita, Daisuke; Okubo, Keishi; Sasaki, Ken; Tsuruda, Yusuke; Kita, Yoshiaki; Mori, Shinichiro; Yanagita, Shigehiro; Uenosono, Yoshikazu; Kurahara, Hiroshi; Ohtsuka, Takao.
Affiliation
  • Arigami T; Department of Onco-biological Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan; arigami@m.kufm.kagoshima-u.ac.jp.
  • Matsushita D; Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
  • Okubo K; Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
  • Sasaki K; Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
  • Tsuruda Y; Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
  • Kita Y; Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
  • Mori S; Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
  • Yanagita S; Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
  • Uenosono Y; Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
  • Kurahara H; Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
  • Ohtsuka T; Department of Onco-biological Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Anticancer Res ; 41(6): 3099-3107, 2021 Jun.
Article in En | MEDLINE | ID: mdl-34083303
ABSTRACT
BACKGROUND/

AIM:

To determine the prognostic utility of trastuzumab-based chemotherapy based on human epidermal growth factor receptor 2 (HER2) expression in patients with para-aortic lymph node (PAN) metastasis from gastric cancer. PATIENTS AND

METHODS:

A total of 41 patients with clinical PAN metastasis from gastric cancer who underwent chemotherapy were retrospectively enrolled.

RESULTS:

Eighteen (43.9%) patients had HER2-positive tumors and consequently, received trastuzumab-based chemotherapy. A total of 11 patients underwent surgery. HER2 status was significantly correlated with the number of distant metastatic sites, the presence or absence of trastuzumab-based chemotherapy, and the presence or absence of gastrectomy. HER2-positive patients had significantly better prognosis than HER2-negative patients. Multivariate analysis identified age and trastuzumab-based chemotherapy based on HER2 status as an independent prognostic factor.

CONCLUSION:

Assessing HER2 expression and subsequent trastuzumab-based chemotherapy can be an effective method for determining the prognosis of patients with PAN metastasis from gastric cancer.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aorta / Stomach Neoplasms / Receptor, ErbB-2 / Lymphatic Metastasis Type of study: Prognostic_studies Limits: Female / Humans / Male Language: En Journal: Anticancer Res Year: 2021 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aorta / Stomach Neoplasms / Receptor, ErbB-2 / Lymphatic Metastasis Type of study: Prognostic_studies Limits: Female / Humans / Male Language: En Journal: Anticancer Res Year: 2021 Document type: Article