Boosting 5-ALA-based photodynamic therapy by a liposomal nanomedicine through intracellular iron ion regulation.

Li, Airong; Liang, Chenglin; Xu, Lihua; Wang, Yiyang; Liu, Wei; Zhang, Kaixiang; Liu, Junjie; Shi, Jinjin

Li, Airong; Liang, Chenglin; Xu, Lihua; Wang, Yiyang; Liu, Wei; Zhang, Kaixiang; Liu, Junjie; Shi, Jinjin.

Affiliation

Li A; Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Liang C; Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Xu L; Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Wang Y; Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Liu W; Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Zhang K; Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Liu J; Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Shi J; Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.

Acta Pharm Sin B ; 11(5): 1329-1340, 2021 May.

Article in En | MEDLINE | ID: mdl-34094837

Key words

5-ALA, 5-aminolevulinic acid; 5-Aminolevulinic acid; ALKBH2; Biotransformation interference; CH, cholesterol; CLs, custom liposomes; Ce6, chlorine e6; DFO, deferoxamine; DNA repair inhibition; DOPC, 1,2-dioleoyl-sn-glycero-3-phosphocholine; DOPE, dioleoyl phosphatidy lethanolamine; DPPC, dipalmitoyl-sn-glycero-3-phosphocholine; Drug delivery; FBS, fetal bovine serum; H&E, hematoxylin and eosin; Iron ion regulation; LMPA, low melting point agarose; MFLs, membrane fusion liposomes; Membrane fusion liposomes; NMPA, normal melting point agarose; PDT, photodynamic therapy; PS, photosensitizers; Photodynamic therapy; PpIX, protoporphyrin IX; ROS, reactive oxygen species; SM, sphingomyelin; TUNEL, terminal deoxynucleotidyl trans-ferase dUTP nick end labeling; calcein-AM/PI, calcein-AM/ propidiumiodide

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Acta Pharm Sin B Year: 2021 Document type: Article Affiliation country: Country of publication:

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