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Recent advances in potential drug therapies combating COVID-19 and related coronaviruses-A perspective.
Nile, Shivraj Hariram; Nile, Arti; Jalde, Shivkumar; Kai, Guoyin.
Affiliation
  • Nile SH; Laboratory of Medicinal Plant Biotechnology, College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, China.
  • Nile A; Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, 05029, South Korea.
  • Jalde S; Department of Medicinal Chemistry, Jungwon University, Goesan, 28420, South Korea.
  • Kai G; Laboratory of Medicinal Plant Biotechnology, College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, China. Electronic address: guoyinkai1@126.com.
Food Chem Toxicol ; 154: 112333, 2021 Aug.
Article in En | MEDLINE | ID: mdl-34118347
Coronaviruses (CoVs) are a large family of viruses responsible for the severe pathophysiological effects on human health. The most severe outbreak includes Severe Acute Respiratory Syndrome (SARS-CoV), Middle East Respiratory Syndrome (MERS-CoV) and Coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2). The COVID-19 poses major challenges to clinical management because no specific FDA-approved therapy yet to be available. Thus, the existing therapies are being used for the treatment of COVID-19, which are under clinical trials and compassionate use, based on in vitro and in silico studies. In this review, we summarize the potential therapies utilizing small molecules, bioactive compounds, nucleoside and nucleotide analogs, peptides, antibodies, natural products, and synthetic compounds targeting the complex molecular signaling network involved in COVID-19. In this review>230 natural and chemically synthesized drug therapies are described with their recent advances in research and development being done in terms of their chemical, structural and functional properties. This review focuses on possible targets for viral cells, viral proteins, viral replication, and different molecular pathways for the discovery of novel viral- and host-based therapeutic targets against SARS-CoV-2.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / SARS-CoV-2 / COVID-19 Drug Treatment Limits: Humans Language: En Journal: Food Chem Toxicol Year: 2021 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / SARS-CoV-2 / COVID-19 Drug Treatment Limits: Humans Language: En Journal: Food Chem Toxicol Year: 2021 Document type: Article Affiliation country: Country of publication: