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Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection.
Oliva Chávez, Adela S; Wang, Xiaowei; Marnin, Liron; Archer, Nathan K; Hammond, Holly L; Carroll, Erin E McClure; Shaw, Dana K; Tully, Brenden G; Buskirk, Amanda D; Ford, Shelby L; Butler, L Rainer; Shahi, Preeti; Morozova, Kateryna; Clement, Cristina C; Lawres, Lauren; Neal, Anya J O'; Mamoun, Choukri Ben; Mason, Kathleen L; Hobbs, Brandi E; Scoles, Glen A; Barry, Eileen M; Sonenshine, Daniel E; Pal, Utpal; Valenzuela, Jesus G; Sztein, Marcelo B; Pasetti, Marcela F; Levin, Michael L; Kotsyfakis, Michail; Jay, Steven M; Huntley, Jason F; Miller, Lloyd S; Santambrogio, Laura; Pedra, Joao H F.
Affiliation
  • Oliva Chávez AS; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Wang X; Department of Entomology, Texas A&M University, College Station, TX, USA.
  • Marnin L; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Archer NK; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Hammond HL; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Carroll EEM; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Shaw DK; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Tully BG; Excerpta Medica, Doylestown, PA, USA.
  • Buskirk AD; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Ford SL; Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA, USA.
  • Butler LR; Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
  • Shahi P; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Morozova K; Center for Drug Evaluation and Research, Office of Pharmaceutical Quality, Office of Process and Facilities, Division of Microbiology Assessment, Microbiology Assessment Branch III, U.S. Food and Drug Administration, Silver Spring, MD, USA.
  • Clement CC; Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Lawres L; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Neal AJO; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Mamoun CB; Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Mason KL; Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Hobbs BE; Department of Radiation Oncology and Physiology and Biophysics, Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Scoles GA; Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
  • Barry EM; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Sonenshine DE; Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
  • Pal U; USDA, ARS, Animal Disease Research Unit, Washington State University, Pullman, WA, USA.
  • Valenzuela JG; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Sztein MB; USDA, ARS, Animal Disease Research Unit, Washington State University, Pullman, WA, USA.
  • Pasetti MF; USDA, ARS, Invasive Insect Biocontrol and Behavior Laboratory, Beltsville, MD, USA.
  • Levin ML; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Kotsyfakis M; Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
  • Jay SM; Department of Biological Sciences, Old Dominion University, Norfolk, VA, USA.
  • Huntley JF; Department of Veterinary Medicine, University of Maryland, College Park, MD, USA.
  • Miller LS; Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
  • Santambrogio L; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Pedra JHF; Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA.
Nat Commun ; 12(1): 3696, 2021 06 17.
Article in En | MEDLINE | ID: mdl-34140472
ABSTRACT
Extracellular vesicles are thought to facilitate pathogen transmission from arthropods to humans and other animals. Here, we reveal that pathogen spreading from arthropods to the mammalian host is multifaceted. Extracellular vesicles from Ixodes scapularis enable tick feeding and promote infection of the mildly virulent rickettsial agent Anaplasma phagocytophilum through the SNARE proteins Vamp33 and Synaptobrevin 2 and dendritic epidermal T cells. However, extracellular vesicles from the tick Dermacentor andersoni mitigate microbial spreading caused by the lethal pathogen Francisella tularensis. Collectively, we establish that tick extracellular vesicles foster distinct outcomes of bacterial infection and assist in vector feeding by acting on skin immunity. Thus, the biology of arthropods should be taken into consideration when developing strategies to control vector-borne diseases.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin / Ticks / Bacterial Infections / Extracellular Vesicles Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin / Ticks / Bacterial Infections / Extracellular Vesicles Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country: