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Novel pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione (PBD) derivatives as selective HDAC6 inhibitors to suppress tumor metastasis and invasion in vitro and in vivo.
Li, Yanchun; Quan, Jishun; Song, Haoxuan; Li, Dongzhu; Ma, Enlong; Wang, Yanjuan; Ma, Chao.
Affiliation
  • Li Y; School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, PR China.
  • Quan J; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, PR China.
  • Song H; School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, PR China.
  • Li D; School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, PR China.
  • Ma E; School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, PR China.
  • Wang Y; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, PR China. Electronic address: yanjuan00836@sina.com.
  • Ma C; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, PR China. Electronic address: machao_syphu@163.com.
Bioorg Chem ; 114: 105081, 2021 09.
Article in En | MEDLINE | ID: mdl-34153811
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzodiazepinones / Histone Deacetylase Inhibitors / Histone Deacetylase 6 / Antineoplastic Agents Limits: Humans Language: En Journal: Bioorg Chem Year: 2021 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzodiazepinones / Histone Deacetylase Inhibitors / Histone Deacetylase 6 / Antineoplastic Agents Limits: Humans Language: En Journal: Bioorg Chem Year: 2021 Document type: Article Country of publication: