Palladium-catalyzed cascade carbonylative annulation between alkene-tethered aryl iodides and carbon monoxide.
Chem Commun (Camb)
; 57(57): 7023-7026, 2021 Jul 21.
Article
in En
| MEDLINE
| ID: mdl-34165470
ABSTRACT
Rapid construction of molecules bearing all-substituted quaternary stereocenters represents a highly significant but challenging task in organic synthesis. Herein, we report a novel palladium-catalyzed cascade between alkene-tethered aryl iodides and carbon monoxide, which has resulted in a practical and powerful method for the synthesis of complex polycyclic molecules containing aryl-substituted quaternary stereocenters. Mechanistic studies suggested that the reaction proceeded via a Heck-type carbonylative cyclization, followed by a ketene-involved Friedel-Crafts acylation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Chem Commun (Camb)
Journal subject:
QUIMICA
Year:
2021
Document type:
Article
Affiliation country: