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In-vitro activity of cefiderocol, cefepime/zidebactam, cefepime/enmetazobactam, omadacycline, eravacycline and other comparative agents against carbapenem-nonsusceptible Enterobacterales: results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART) in 2017-2020.
Lee, Yu-Lin; Ko, Wen-Chien; Lee, Wen-Sen; Lu, Po-Liang; Chen, Yen-Hsu; Cheng, Shu-Hsing; Lu, Min-Chi; Lin, Chi-Ying; Wu, Ting-Shu; Yen, Muh-Yong; Wang, Lih-Shinn; Liu, Chang-Pan; Shao, Pei-Lan; Shi, Zhi-Yuan; Chen, Yao-Shen; Wang, Fu-Der; Tseng, Shu-Hui; Lin, Chao-Nan; Chen, Yu-Hui; Sheng, Wang-Huei; Lee, Chun-Ming; Tang, Hung-Jen; Hsueh, Po-Ren.
Affiliation
  • Lee YL; Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan, and Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung, Taiwan.
  • Ko WC; Department of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Lee WS; Division of Infectious Diseases, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, and Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
  • Lu PL; Department of Internal Medicine, Kaohsiung Medical University Hospital, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
  • Chen YH; Department of Internal Medicine, Kaohsiung Medical University Hospital, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
  • Cheng SH; Department of Internal Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, and School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan.
  • Lu MC; Department of Microbiology and Immunology, School of Medicine, China Medical University, Taichung, Taiwan.
  • Lin CY; Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan.
  • Wu TS; Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan.
  • Yen MY; Division of Infectious Diseases, Taipei City Hospital, and National Yang-Ming University, School of Medicine, Taipei, Taiwan.
  • Wang LS; Division of Infectious Diseases, Department of Internal Medicine, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan.
  • Liu CP; Division of Infectious Diseases, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan, and MacKay Medical College, New Taipei City, Taiwan.
  • Shao PL; Department of Paediatrics, Hsin-Chu Branch, National Taiwan University Hospital, Hsin-Chu, Taiwan.
  • Shi ZY; Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Chen YS; Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, and School of Medicine, National Yang-Ming University, Taipei, Taiwan.
  • Wang FD; Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, and School of Medicine, National Yang-Ming University, Taipei, Taiwan.
  • Tseng SH; Centre for Disease Control and Prevention, Ministry of Health and Welfare, Taiwan.
  • Lin CN; Department of Veterinary Medicine, and Animal Disease Diagnostic Centre, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung, Taiwan.
  • Chen YH; Infection Control Centre, Chi Mei Hospital, Liouying, Taiwan.
  • Sheng WH; Division of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
  • Lee CM; Department of Internal Medicine, St Joseph's Hospital, Yunlin County, Taiwan, and MacKay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan.
  • Tang HJ; Department of Medicine, Chi Mei Medical Centre, Tainan, Taiwan.
  • Hsueh PR; Division of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwa
Int J Antimicrob Agents ; 58(3): 106377, 2021 Sep.
Article in En | MEDLINE | ID: mdl-34166777
ABSTRACT
This study examined the susceptibility of carbapenem-nonsusceptible Enterobacterales (CNSE) to cefiderocol, cefepime/zidebactam, cefepime/enmetazobactam, omadacycline, eravacycline and other comparative agents. Non-duplicate Enterobacterales isolates from 16 Taiwanese hospitals were evaluated. Minimum inhibitory concentrations (MICs) were determined using the broth microdilution method, and susceptibility results were interpreted based on relevant guidelines. In total, 201 CNSE isolates were investigated, including 26 Escherichia coli isolates and 175 Klebsiella pneumoniae isolates. Carbapenemase genes were detected in 15.4% (n=4) of E. coli isolates and 47.4% (n=83) of K. pneumoniae isolates, with the most common being blaKPC (79.3%, 69/87), followed by blaOXA-48-like (13.8%, 12/87). Cefiderocol was the most active agent against CNSE; only 3.8% (n=1) of E. coli isolates and 4.6% (n=8) of K. pneumoniae isolates were not susceptible to cefiderocol. Among the carbapenem-resistant E. coli and K. pneumoniae isolates, 88.5% (n=23) and 93.7% (n=164), respectively, were susceptible to ceftazidime/avibactam. For cefepime/zidebactam, 23 (88.5%) E. coli isolates and 155 (88.6%) K. pneumoniae isolates had MICs ≤2/2 mg/L. For cefepime/enmetazobactam, 22 (84.6%) E. coli isolates and 85 (48.6%) K. pneumoniae isolates had MICs ≤2/8 mg/L. The higher MICs of K. pneumoniae against cefepime/enmetazobactam were due to only one (1.5%) of the 67 blaKPC-carrying isolates being susceptible. MICs of omadacycline were significantly higher than those of eravacycline and tigecycline. In summary, cefiderocol, ceftazidime/avibactam and cefepime/zidebactam were more effective against carbapenem-nonsusceptible E. coli and K. pneumoniae than other drugs, highlighting their potential as valuable therapeutics.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Klebsiella Infections / Drug Resistance, Bacterial / Drug Combinations / Escherichia coli / Escherichia coli Infections / Klebsiella pneumoniae / Anti-Bacterial Agents Type of study: Guideline / Screening_studies Limits: Humans Country/Region as subject: Asia Language: En Journal: Int J Antimicrob Agents Year: 2021 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Klebsiella Infections / Drug Resistance, Bacterial / Drug Combinations / Escherichia coli / Escherichia coli Infections / Klebsiella pneumoniae / Anti-Bacterial Agents Type of study: Guideline / Screening_studies Limits: Humans Country/Region as subject: Asia Language: En Journal: Int J Antimicrob Agents Year: 2021 Document type: Article Affiliation country: