Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats.

Dahlgren, David; Olander, Tobias; Sjöblom, Markus; Hedeland, Mikael; Lennernäs, Hans

Dahlgren, David; Olander, Tobias; Sjöblom, Markus; Hedeland, Mikael; Lennernäs, Hans.

Affiliation

Dahlgren D; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala 752 36, Sweden.
Olander T; Department of Pharmaceutical Biosciences, Translational Drug Discovery and Development, Uppsala University, Uppsala 752 36, Sweden.
Sjöblom M; Department of Neuroscience, Division of Physiology, Uppsala University, Uppsala 752 36, Sweden.
Hedeland M; Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry, Uppsala University, Uppsala 752 36, Sweden.
Lennernäs H; Department of Chemistry, Environment and Feed Hygiene, National Veterinary Institute (SVA), Uppsala 751 89, Sweden.

Acta Pharm Sin B ; 11(6): 1667-1675, 2021 Jun.

Article in En | MEDLINE | ID: mdl-34221875

Key words

Absorption-modifying excipients; CLCr-EDTA, clearance of 51Cr-EDTA; Intestinal perfusion; Intestinal permeability; Oral peptide delivery; PE, permeation enhancer; Peff, intestinal effective permeability; Permeation enhancers; Pharmaceutical development; SDS, sodium dodecyl sulfate; SPIP, single-pass intestinal perfusion

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Acta Pharm Sin B Year: 2021 Document type: Article Affiliation country:

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Acta Pharm Sin B Year: 2021 Document type: Article Affiliation country: