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Stabilization of telomeric G-quadruplex by ligand binding increases susceptibility to S1 nuclease.
Ishikawa, Ryo; Yasuda, Mizuho; Sasaki, Shogo; Ma, Yue; Nagasawa, Kazuo; Tera, Masayuki.
Affiliation
  • Ishikawa R; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan. knaga@cc.tuat.ac.jp.
  • Yasuda M; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan. knaga@cc.tuat.ac.jp.
  • Sasaki S; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan. knaga@cc.tuat.ac.jp.
  • Ma Y; Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.
  • Nagasawa K; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan. knaga@cc.tuat.ac.jp.
  • Tera M; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan. knaga@cc.tuat.ac.jp.
Chem Commun (Camb) ; 57(59): 7236-7239, 2021 Jul 28.
Article in En | MEDLINE | ID: mdl-34263271
ABSTRACT
The extent of thermodynamic stabilization of telomeric G-quadruplex (G4) by isomers of G4 ligand L2H2-6OTD, a telomestatin analog, is inversely correlated with susceptibility to S1 nuclease. L2H2-6OTD facilitated the S1 nuclease activities through the base flipping in G4, unlike the conventional role of G4 ligands which inhibit the protein binding to DNA/RNA upon ligand interactions.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Single-Strand Specific DNA and RNA Endonucleases / G-Quadruplexes Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2021 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Single-Strand Specific DNA and RNA Endonucleases / G-Quadruplexes Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2021 Document type: Article Affiliation country: