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Reduced Acrolein Detoxification in akr1a1a Zebrafish Mutants Causes Impaired Insulin Receptor Signaling and Microvascular Alterations.
Qi, Haozhe; Schmöhl, Felix; Li, Xiaogang; Qian, Xin; Tabler, Christoph T; Bennewitz, Katrin; Sticht, Carsten; Morgenstern, Jakob; Fleming, Thomas; Volk, Nadine; Hausser, Ingrid; Heidenreich, Elena; Hell, Rüdiger; Nawroth, Peter Paul; Kroll, Jens.
Affiliation
  • Qi H; Department of Vascular Biology and Tumor Angiogenesis, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, 68167, Germany.
  • Schmöhl F; Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
  • Li X; Department of Vascular Biology and Tumor Angiogenesis, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, 68167, Germany.
  • Qian X; Department of Vascular Biology and Tumor Angiogenesis, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, 68167, Germany.
  • Tabler CT; Department of Vascular Biology and Tumor Angiogenesis, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, 68167, Germany.
  • Bennewitz K; Department of Vascular Biology and Tumor Angiogenesis, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, 68167, Germany.
  • Sticht C; Department of Vascular Biology and Tumor Angiogenesis, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, 68167, Germany.
  • Morgenstern J; NGS Core Facility, Medical Faculty Mannheim, Heidelberg University, Mannheim, 68167, Germany.
  • Fleming T; Department of Internal Medicine I and Clinical Chemistry, Heidelberg University Hospital, Heidelberg, 69120, Germany.
  • Volk N; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany.
  • Hausser I; Department of Internal Medicine I and Clinical Chemistry, Heidelberg University Hospital, Heidelberg, 69120, Germany.
  • Heidenreich E; German Center for Diabetes Research (DZD), Neuherberg, 85764, Germany.
  • Hell R; Tissue Bank of the National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg University, Heidelberg, 69120, Germany.
  • Nawroth PP; Institute of Pathology IPH, EM Lab, Heidelberg University Hospital, Heidelberg, 69120, Germany.
  • Kroll J; Metabolomics Core Technology Platform, Centre for Organismal Studies, Heidelberg University, Heidelberg, 69120, Germany.
Adv Sci (Weinh) ; 8(18): e2101281, 2021 09.
Article in En | MEDLINE | ID: mdl-34278746
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acrolein / Receptor, Insulin / Diabetes Mellitus, Experimental / Glucose / Liver Type of study: Etiology_studies Limits: Animals Language: En Journal: Adv Sci (Weinh) Year: 2021 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acrolein / Receptor, Insulin / Diabetes Mellitus, Experimental / Glucose / Liver Type of study: Etiology_studies Limits: Animals Language: En Journal: Adv Sci (Weinh) Year: 2021 Document type: Article Affiliation country: Country of publication: