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Biotinylated Mn3O4 nanocuboids for targeted delivery of gemcitabine hydrochloride to breast cancer and MRI applications.
Jain, Poonam; Patel, Krunal; Jangid, Ashok Kumar; Guleria, Anupam; Patel, Sunita; Pooja, Deep; Kulhari, Hitesh.
Affiliation
  • Jain P; School of Nano Sciences, Central University of Gujarat, Gandhinagar 382030, India.
  • Patel K; School of Life Sciences, Central University of Gujarat, Gandhinagar 382030, India.
  • Jangid AK; School of Nano Sciences, Central University of Gujarat, Gandhinagar 382030, India.
  • Guleria A; Centre of Biomedical Research, SGPGIMS Campus, Lucknow 226014, India.
  • Patel S; School of Life Sciences, Central University of Gujarat, Gandhinagar 382030, India.
  • Pooja D; The Centre for Advanced Materials & Industrial Chemistry, School of Science, RMIT University, Melbourne, Victoria 3001, Australia. Electronic address: d.dpooja00@gmail.com.
  • Kulhari H; School of Nano Sciences, Central University of Gujarat, Gandhinagar 382030, India. Electronic address: hitesh.kulhari@cug.ac.in.
Int J Pharm ; 606: 120895, 2021 Sep 05.
Article in En | MEDLINE | ID: mdl-34280487
Multifunctional nanocarriers have been found as potential candidate for the targeted drug delivery and imaging applications. Herein, we have developed a biocompatible and pH-responsive manganese oxide nanocuboid system, surface modified with poly (ethylene glycol) bis(amine) and functionalized with biotin (Biotin-PEG-MNCs), for an efficient and targeted delivery of an anticancer drug (gemcitabine, GEM) to the human breast cancer cells. GEM-loaded Biotin-PEG@MNCs showed high drug loading efficiency, controlled release of GEM and excellent storage stability in the physiological buffers and different temperature conditions. GEM-loaded Biotin-PEG@MNCs showed dose- and time-dependent decrease in the viability of human breast cancer cells. Further, it exhibited significantly higher cell growth inhibition than pure GEM which suggested that Biotin-PEG@MNCs has efficiently delivered the GEM into cancerous cells. The role of biotin in the uptake was proved by the competitive binding-based cellular uptake study. A significant decrease in the amount of manganese was observed in biotin pre-treated cancer cells as compared to biotin untreated cancer cells. In MRI studies, Biotin-PEG-MNCs showed both longitudinal and transverse relaxivity about 0.091 and 7.66 mM-1 s-1 at 3.0 T MRI scanner, respectively. Overall, the developed Biotin-PEG-MNCs presents a significant potential in formulation development for cancer treatment via targeted drug delivery and enhanced MRI contrast imaging properties.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Nanoparticles Limits: Female / Humans Language: En Journal: Int J Pharm Year: 2021 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Nanoparticles Limits: Female / Humans Language: En Journal: Int J Pharm Year: 2021 Document type: Article Affiliation country: Country of publication: