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Performing radiosynthesis in microvolumes to maximize molar activity of tracers for positron emission tomography.
Sergeev, Maxim E; Lazari, Mark; Morgia, Federica; Collins, Jeffrey; Javed, Muhammad Rashed; Sergeeva, Olga; Jones, Jason; Phelps, Michael E; Lee, Jason T; Keng, Pei Yuin; van Dam, R Michael.
Affiliation
  • Sergeev ME; Crump Institute for Molecular Imaging, University of California, Los Angeles (UCLA), 570 Westwood Plaza, Los Angeles, CA, USA, 90095.
  • Lazari M; Department of Molecular & Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), 650 Charles E. Young Dr. S., Los Angeles, CA, USA, 90095.
  • Morgia F; Crump Institute for Molecular Imaging, University of California, Los Angeles (UCLA), 570 Westwood Plaza, Los Angeles, CA, USA, 90095.
  • Collins J; Department of Molecular & Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), 650 Charles E. Young Dr. S., Los Angeles, CA, USA, 90095.
  • Javed MR; Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, UCLA, Los Angeles, CA, USA.
  • Sergeeva O; Crump Institute for Molecular Imaging, University of California, Los Angeles (UCLA), 570 Westwood Plaza, Los Angeles, CA, USA, 90095.
  • Jones J; Department of Molecular & Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), 650 Charles E. Young Dr. S., Los Angeles, CA, USA, 90095.
  • Phelps ME; Crump Institute for Molecular Imaging, University of California, Los Angeles (UCLA), 570 Westwood Plaza, Los Angeles, CA, USA, 90095.
  • Lee JT; Department of Molecular & Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), 650 Charles E. Young Dr. S., Los Angeles, CA, USA, 90095.
  • Keng PY; Crump Institute for Molecular Imaging, University of California, Los Angeles (UCLA), 570 Westwood Plaza, Los Angeles, CA, USA, 90095.
  • van Dam RM; Department of Molecular & Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), 650 Charles E. Young Dr. S., Los Angeles, CA, USA, 90095.
Commun Chem ; 1(1)2018.
Article in En | MEDLINE | ID: mdl-34291178
Positron emission tomography (PET) is a molecular diagnostic imaging technology to quantitatively visualize biological processes in vivo. For many applications, including imaging of low tissue density targets (e.g. neuroreceptors), imaging in small animals, and evaluation of novel tracers, the injected PET tracer must be produced with high molar activity to ensure low occupancy of biological targets and avoid pharmacologic effects. Additionally, high molar activity is essential for tracers with lengthy syntheses or tracers transported to distant imaging sites. We show that radiosynthesis of PET tracers in microliter volumes instead of conventional milliliter volumes results in substantially increased molar activity, and we identify the most relevant variables affecting this parameter. Furthermore, using the PET tracer [18F]fallypride, we illustrate that molar activity can have a significant impact on biodistribution. With full automation, microdroplet platforms could provide a means for radiochemists to routinely, conveniently, and safely produce PET tracers with high molar activity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Commun Chem Year: 2018 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Commun Chem Year: 2018 Document type: Article Country of publication: