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Biparametric Magnetic Resonance Imaging-Derived Nomogram to Detect Clinically Significant Prostate Cancer by Targeted Biopsy for Index Lesion.
Kim, Min Je; Park, Sung Yoon.
Affiliation
  • Kim MJ; Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  • Park SY; Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
J Magn Reson Imaging ; 55(4): 1226-1233, 2022 Apr.
Article in En | MEDLINE | ID: mdl-34296803
ABSTRACT

BACKGROUND:

Currently, it is necessary to investigate how to combine biparametric magnetic resonance imaging (bpMRI) with various clinical parameters for the detection of clinically significant prostate cancer (csPCa).

PURPOSE:

To develop a multivariate prebiopsy nomogram using clinical and bpMRI parameters for estimating the probability of csPCa. STUDY TYPE Retrospective, single-center study.

SUBJECTS:

Two hundred and twenty-six patients who underwent targeted biopsy (TBx) for the MRI-suspected index lesion because of clinical suspicions of PCa. FIELD STRENGTH/SEQUENCE A 3 T MRI including turbo spin-echo T2 -weighted and diffusion-weighted single-shot echo-planar imaging sequences. ASSESSMENT Prebiopsy clinical and bpMRI parameters were patient age, biopsy history (biopsy-naïve or repeated biopsy status), prostate-specific antigen density (PSAD), Prostate Imaging-Reporting and Data System version 2.1 (PI-RADSv2.1), and apparent diffusion coefficient ratio (ADCR). ADCR was defined as mean ADC of the index lesion divided by mean ADC of the contralateral prostatic region. A multivariate prebiopsy nomogram for csPCa (i.e. Gleason sum ≥7) was developed. Area under the curve (AUC) of each parameter and prebiopsy nomogram was assessed. Five-fold cross-validation was performed for robust estimation of performance of the prebiopsy nomogram. STATISTICAL TESTS Logistic regression, receiver-operating curve, and 5-fold cross-validation. P-value < 0.05 was considered statistically significant.

RESULTS:

Proportion of csPCa was 31.9% (72/226). The AUCs of age, biopsy-naïve status, PSAD, PI-RADSv2.1, ADCR, and prebiopsy nomogram were 0.657 (95% confidence interval [CI], 0.580-0.733), 0.593 (95% CI, 0.525-0.660), 0.762 (95% CI, 0.697-0.826), 0.824 (95% CI, 0.770-0.878), 0.829 (95% CI, 0.769-0.888), and 0.906 (95% CI, 0.863-0.948), respectively AUC of nomogram was significantly different than that of individual parameter. In the 5-fold cross-validation, the mean AUC of the prebiopsy nomogram for csPCa was 0.888 (95% CI, 0.786-0.983). DATA

CONCLUSIONS:

This multivariate prebiopsy nomogram using clinical and bpMRI parameters may help estimate the probability of csPCa in patients undergoing TBx. ADCR seems to enhance the role of bpMRI in detecting csPCa. LEVEL OF EVIDENCE 3 TECHNICAL EFFICACY Stage 2.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Nomograms Type of study: Observational_studies / Prognostic_studies Limits: Humans / Male Language: En Journal: J Magn Reson Imaging Journal subject: DIAGNOSTICO POR IMAGEM Year: 2022 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Nomograms Type of study: Observational_studies / Prognostic_studies Limits: Humans / Male Language: En Journal: J Magn Reson Imaging Journal subject: DIAGNOSTICO POR IMAGEM Year: 2022 Document type: Article
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