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Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy.
Wu, Hsin-Chieh; Rérolle, Domitille; Berthier, Caroline; Hleihel, Rita; Sakamoto, Takashi; Quentin, Samuel; Benhenda, Shirine; Morganti, Claudia; Wu, Chengchen; Conte, Lidio; Rimsky, Sylvie; Sebert, Marie; Clappier, Emmanuelle; Souquere, Sylvie; Gachet, Stéphanie; Soulier, Jean; Durand, Sylvère; Trowbridge, Jennifer J; Bénit, Paule; Rustin, Pierre; El Hajj, Hiba; Raffoux, Emmanuel; Ades, Lionel; Itzykson, Raphael; Dombret, Hervé; Fenaux, Pierre; Espeli, Olivier; Kroemer, Guido; Brunetti, Lorenzo; Mak, Tak W; Lallemand-Breitenbach, Valérie; Bazarbachi, Ali; Falini, Brunangelo; Ito, Keisuke; Martelli, Maria Paola; de Thé, Hugues.
Affiliation
  • Wu HC; Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, INSERM UMR 1050, CNRS UMR 7241, Paris, France.
  • Rérolle D; Université de Paris, INSERM U944, CNRS UMR 7212, IRSL, Hôpital St. Louis, Paris, France.
  • Berthier C; Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, INSERM UMR 1050, CNRS UMR 7241, Paris, France.
  • Hleihel R; Université de Paris, INSERM U944, CNRS UMR 7212, IRSL, Hôpital St. Louis, Paris, France.
  • Sakamoto T; Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, INSERM UMR 1050, CNRS UMR 7241, Paris, France.
  • Quentin S; Université de Paris, INSERM U944, CNRS UMR 7212, IRSL, Hôpital St. Louis, Paris, France.
  • Benhenda S; Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, INSERM UMR 1050, CNRS UMR 7241, Paris, France.
  • Morganti C; Université de Paris, INSERM U944, CNRS UMR 7212, IRSL, Hôpital St. Louis, Paris, France.
  • Wu C; Department of Internal Medicine and Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Beirut, Lebanon.
  • Conte L; Department of Experimental Pathology, Microbiology and Immunology, American University of Beirut, Beirut, Lebanon.
  • Rimsky S; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Sebert M; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Clappier E; Université de Paris, INSERM U944, CNRS UMR 7212, IRSL, Hôpital St. Louis, Paris, France.
  • Souquere S; Université de Paris, INSERM U944, CNRS UMR 7212, IRSL, Hôpital St. Louis, Paris, France.
  • Gachet S; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research and Departments of Cell Biology and Medicine, Albert Einstein College of Medicine, Bronx, New York.
  • Soulier J; Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, INSERM UMR 1050, CNRS UMR 7241, Paris, France.
  • Durand S; Université de Paris, INSERM U944, CNRS UMR 7212, IRSL, Hôpital St. Louis, Paris, France.
  • Trowbridge JJ; Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, INSERM UMR 1050, CNRS UMR 7241, Paris, France.
  • Bénit P; Université de Paris, INSERM U944, CNRS UMR 7212, IRSL, Hôpital St. Louis, Paris, France.
  • Rustin P; Department of Precision Medicine, University of Campania "Luigi Vanvitelli, " Napoli, Italy.
  • El Hajj H; Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, INSERM UMR 1050, CNRS UMR 7241, Paris, France.
  • Raffoux E; Université de Paris, INSERM U944, CNRS UMR 7212, IRSL, Hôpital St. Louis, Paris, France.
  • Ades L; Department of Hematology, Hôpital Saint Louis (Assistance publique Hôpitaux de Paris) and Paris University, Paris, France.
  • Itzykson R; Université de Paris, INSERM U944, CNRS UMR 7212, IRSL, Hôpital St. Louis, Paris, France.
  • Dombret H; Department of Hematology, Hôpital Saint Louis (Assistance publique Hôpitaux de Paris) and Paris University, Paris, France.
  • Fenaux P; Institut Gustave Roussy, Cell Biology and Metabolomics Platforms, INSERM UMS 3655, Villejuif, France.
  • Espeli O; Université de Paris, INSERM U944, CNRS UMR 7212, IRSL, Hôpital St. Louis, Paris, France.
  • Kroemer G; Université de Paris, INSERM U944, CNRS UMR 7212, IRSL, Hôpital St. Louis, Paris, France.
  • Brunetti L; Department of Hematology, Hôpital Saint Louis (Assistance publique Hôpitaux de Paris) and Paris University, Paris, France.
  • Mak TW; Institut Gustave Roussy, Cell Biology and Metabolomics Platforms, INSERM UMS 3655, Villejuif, France.
  • Lallemand-Breitenbach V; The Jackson Laboratory, Bar Harbor, Maine.
  • Bazarbachi A; INSERM, U1141 Hôpital Robert Debré, Paris France.
  • Falini B; INSERM, U1141 Hôpital Robert Debré, Paris France.
  • Ito K; Department of Experimental Pathology, Microbiology and Immunology, American University of Beirut, Beirut, Lebanon.
  • Martelli MP; Department of Hematology, Hôpital Saint Louis (Assistance publique Hôpitaux de Paris) and Paris University, Paris, France.
  • de Thé H; Université de Paris, INSERM U944, CNRS UMR 7212, IRSL, Hôpital St. Louis, Paris, France.
Cancer Discov ; 11(12): 3198-3213, 2021 12 01.
Article in En | MEDLINE | ID: mdl-34301789
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Leukemia, Myeloid, Acute Limits: Humans Language: En Journal: Cancer Discov Year: 2021 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Leukemia, Myeloid, Acute Limits: Humans Language: En Journal: Cancer Discov Year: 2021 Document type: Article Affiliation country: