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Model-Based Drug-Drug Interaction Extrapolation Strategy From Adults to Children: Risdiplam in Pediatric Patients With Spinal Muscular Atrophy.
Cleary, Yumi; Gertz, Michael; Grimsey, Paul; Günther, Andreas; Heinig, Katja; Ogungbenro, Kayode; Aarons, Leon; Galetin, Aleksandra; Kletzl, Heidemarie.
Affiliation
  • Cleary Y; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center, Basel, Switzerland.
  • Gertz M; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK.
  • Grimsey P; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center, Basel, Switzerland.
  • Günther A; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center, Welwyn, UK.
  • Heinig K; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center, Basel, Switzerland.
  • Ogungbenro K; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center, Basel, Switzerland.
  • Aarons L; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK.
  • Galetin A; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK.
  • Kletzl H; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK.
Clin Pharmacol Ther ; 110(6): 1547-1557, 2021 12.
Article in En | MEDLINE | ID: mdl-34347881
Subject(s)
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Azo Compounds / Muscular Atrophy, Spinal / Drug Interactions / Cytochrome P-450 CYP3A Inhibitors / Models, Biological / Neuromuscular Agents Type of study: Prognostic_studies Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Language: En Journal: Clin Pharmacol Ther Year: 2021 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Azo Compounds / Muscular Atrophy, Spinal / Drug Interactions / Cytochrome P-450 CYP3A Inhibitors / Models, Biological / Neuromuscular Agents Type of study: Prognostic_studies Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Language: En Journal: Clin Pharmacol Ther Year: 2021 Document type: Article Affiliation country: Country of publication: