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Synthesis and Catalytic Activities of 3-Decyl-ß-proline for Michael Reactions in Water without an Organic Solvent.
Nagata, Kazuhiro; Nakagawa, Chihiro; Yokoyama, Wakana; Usui, Haruka; Mochizuki, Rikako; Kanemitsu, Takuya; Miyazaki, Michiko; Itoh, Takashi.
Affiliation
  • Nagata K; School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
  • Nakagawa C; School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
  • Yokoyama W; School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
  • Usui H; School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
  • Mochizuki R; School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
  • Kanemitsu T; School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
  • Miyazaki M; School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
  • Itoh T; School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
ACS Omega ; 6(30): 19642-19646, 2021 Aug 03.
Article in En | MEDLINE | ID: mdl-34368551
3-Decyl-ß-proline, which has a highly lipophilic substituent, was synthesized, and its catalytic activities in Michael addition using water as the solvent were investigated. The decyl substituent promoted the reaction by hydrophobic interactions to afford the Michael adduct in a high yield and with high diastereoselectivity under low catalyst loading.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: ACS Omega Year: 2021 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: ACS Omega Year: 2021 Document type: Article Affiliation country: Country of publication: