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Elevated complement mediator levels in endothelial-derived plasma exosomes implicate endothelial innate inflammation in diminished brain function of aging humans.
Elahi, Fanny M; Harvey, Danielle; Altendahl, Marie; Brathaban, Nivetha; Fernandes, Nicole; Casaletto, Kaitlin B; Staffaroni, Adam M; Maillard, Pauline; Hinman, Jason D; Miller, Bruce L; DeCarli, Charles; Kramer, Joel H; Goetzl, Edward J.
Affiliation
  • Elahi FM; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. elahilab15@gmail.com.
  • Harvey D; Department of Public Health Sciences, University of California, Davis, Davis, CA, USA.
  • Altendahl M; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
  • Brathaban N; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
  • Fernandes N; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
  • Casaletto KB; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
  • Staffaroni AM; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
  • Maillard P; Department of Neurology and Center for Neuroscience, University of California, Davis, Davis, CA, USA.
  • Hinman JD; Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA.
  • Miller BL; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
  • DeCarli C; Department of Neurology and Center for Neuroscience, University of California, Davis, Davis, CA, USA.
  • Kramer JH; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
  • Goetzl EJ; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. edward.goetzl@ucsf.edu.
Sci Rep ; 11(1): 16198, 2021 08 10.
Article in En | MEDLINE | ID: mdl-34376699
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Complement System Proteins / Cerebrovascular Disorders / Endothelial Cells / Exosomes / Cognitive Dysfunction / Inflammation Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Aged80 / Female / Humans / Male Country/Region as subject: America do norte Language: En Journal: Sci Rep Year: 2021 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Complement System Proteins / Cerebrovascular Disorders / Endothelial Cells / Exosomes / Cognitive Dysfunction / Inflammation Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Aged80 / Female / Humans / Male Country/Region as subject: America do norte Language: En Journal: Sci Rep Year: 2021 Document type: Article Affiliation country: