Distribution of Pathogens in Elderly Chinese Patients With Pneumonia: A Systematic Review and Meta-Analysis.
Front Med (Lausanne)
; 8: 584066, 2021.
Article
in En
| MEDLINE
| ID: mdl-34381791
ABSTRACT
Background:
To summarize the distribution of pathogenic bacteria in elderly Chinese patients with pneumonia and provide guidance for the clinical application of antibiotics.Methods:
The electronic databases of PubMed, Embase, Cochrane library, and China National Knowledge Infrastructure were searched. The primary outcomes included the prevalence of gram-positive cocci, gram-negative bacilli, and fungus. The summary prevalence and 95% confidence interval (CI) were calculated using the random-effects model.Results:
A total of 17 retrospective studies reporting a total of 5,729 elderly patients with pneumonia were selected for final analysis. The summary prevalence of gram-positive cocci was 25% (95% CI 20-30%; p < 0.001), whereas the prevalence of gram-negative bacilli was 56% (95% CI 46-67%; p < 0.001). Moreover, the pooled prevalence of fungus in elderly patients with pneumonia was 11% (95% CI 8-14%; p < 0.001). The most common gram-positive cocci were Staphylococcus aureus (ES 8%; 95% CI 6-11%; p <0.001), Streptococcus hemolyticus (ES 7%; 95% CI 6-8%; p < 0.001), and Streptococcus pneumoniae (ES 5%; 95% CI 3-7%; p < 0.001). Pseudomonas aeruginosa (ES 18%; 95% CI 14-22%; p <0.001) and Klebsiella pneumoniae (ES 14%; 95% CI 11-18%; p <0.001) were most common gram-negative bacilli. Furthermore, the pooled prevalence of Candida albicans in elderly patients with pneumonia was 6% (95% CI 5-8%; p < 0.001).Conclusions:
The findings demonstrated the comprehensive distribution of pathogenic bacteria in elderly Chinese patients with pneumonia, which could guide further antibiotic therapies.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Guideline
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Language:
En
Journal:
Front Med (Lausanne)
Year:
2021
Document type:
Article
Affiliation country: