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Codelivery of satraplatin and aminopyrrolic receptor with Pluronic F127-based polyaniline nanoparticles with NIR induced release for combined chemotherapy.
Chen, Dalei; Zhang, Xinzhong; Yang, Jing; Liao, Xiali; Yang, Bo; Gao, Chuanzhu.
Affiliation
  • Chen D; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, People's Republic of China.
  • Zhang X; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, People's Republic of China.
  • Yang J; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, People's Republic of China.
  • Liao X; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, People's Republic of China.
  • Yang B; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, People's Republic of China.
  • Gao C; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, People's Republic of China.
Nanotechnology ; 32(47)2021 Sep 02.
Article in En | MEDLINE | ID: mdl-34388738
The acquired drug resistance of the platinum-based drug is a main obstacle in cancer therapy. Herein, an aminopyrrolic receptor 1 was synthesized to sensitize satraplatin for overcoming the drug resistance as well as improving tumor targeted ability. Thus, Pluronic F127-based polyaniline nanoparticles were designed to co-deliver satraplatin and aminopyrrolic receptor 1, which could control the drug release with the Near Infrared laser irradiation (808 nm) due to the polyaniline mediated photothermal conversion. Biological evaluation shows prepared nanoparticles (Pt-ARNPs) exhibited more effective cytotoxicity (IC50 = 2.7µM) against the tested cancer cell lines under laser irradiation, compared with free satraplatin or treatment without Near-infrared radiation. Moreover, Pt-ARNPs showed comparable cytotoxicity against A549 and A549/cis cells, implying that the combination of satraplatin and aminopyrrolic receptor 1 with nano carrier might be a promising strategy to reduce platinum resistance and improve therapeutic effect in cancer therapy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Nanoparticles / Neoplasms Limits: Humans Language: En Journal: Nanotechnology Year: 2021 Document type: Article Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Nanoparticles / Neoplasms Limits: Humans Language: En Journal: Nanotechnology Year: 2021 Document type: Article Country of publication: