N-acetyl-ß-D-glucosaminidase is predictive of mortality in chronic heart failure: a 10-year follow-up.
Biomark Med
; 15(13): 1143-1153, 2021 09.
Article
in En
| MEDLINE
| ID: mdl-34397265
ABSTRACT
Aim:
The study focused on biomarkers of kidney injury as predictors of mortality in patients with chronic heart failure (CHF) in a long-term follow-up (median 104 months). Methods/results:
KIM-1, NAG and NGAL were assessed from urine, NT-proBNP from blood samples. 149 patients (age 62 ± 12 years) with CHF (mean EF 30% [IQR 24-40%]) were enrolled. 79 (53%) patients died. Cox regression analysis revealed Log2NAG (HR 1.46, CI 1.12-1.89), Log2KIM-1 (HR 1.23, CI 1.02-1.49) and Log2NT-proBNP (HR 1.50, CI 1.32-1.72) as significant predictors of all-cause mortality as opposed to Log2NGAL (HR 1.04, CI 0.90-1.20). Log2NAG remained a significant predictor of all-cause mortality in a multivariate Cox regression model but lost its predictive value in combination with Log2NT-proBNP.Conclusion:
The 10-year follow-up suggests NAG as a predictive tubular marker in CHF patients.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Acetylglucosaminidase
/
Biomarkers
/
Heart Failure
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Biomark Med
Journal subject:
BIOQUIMICA
/
MEDICINA
Year:
2021
Document type:
Article
Affiliation country: