Effects of Soy Protein Containing of Isoflavones and Isoflavones Extract on Plasma Lipid Profile in Postmenopausal Women as a Potential Prevention Factor in Cardiovascular Diseases: Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Nutrients
; 13(8)2021 Jul 24.
Article
in En
| MEDLINE
| ID: mdl-34444691
ABSTRACT
The aim of the report was to evaluate the impact of soy protein containing isoflavones and soy isoflavones extract on lipid profile in postmenopausal women, as compared with placebo or protein of milk, casein or isolated soy protein with or without trace isoflavone content. We used the following databases MEDLINE (PubMed), EMBASE and the Cochrane Library. Quantitative data synthesis was performed by applying a random-effects model. Subgroup analysis and meta-regression were performed to assess the modifiers of treatment response. In total, in the analysis studies, 2305 postmenopausal women took part. Changes in the lipid profile showed statistically significant decreases of total cholesterol by -0.12 (95% CI -0.21, -0.03) mmol/L, -4.64 (95% CI -8.12, -1.16) mg/dL, p = 0.01 and increased HDL-cholesterol by 0.03 (95% CI 0.00, 0.06) mmol/L, 1.15 (95% CI 0.00, 1.93) mg/dL, p = 0.05, as well as in LDL-cholesterol -0.05 (95% CI -0.11, 0.01) mmol/L, -1.93 (95% CI -4.25, 0.39) mg/dL, p = 0.08 and triacylglycerols -0.07 (95% CI -0.14, 0.00) mmol/L, -6.123 (95% CI -12.25, 0.00) mg/dL, p = 0.06. Our results suggests that soy and its isoflavones can be effective in correction changes in lipid metabolism in postmenopausal women and may favorably influence in preventing cardiovascular events.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plant Extracts
/
Cardiovascular Diseases
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Postmenopause
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Soybean Proteins
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Lipids
Type of study:
Clinical_trials
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Prognostic_studies
/
Systematic_reviews
Limits:
Female
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Humans
/
Middle aged
Language:
En
Journal:
Nutrients
Year:
2021
Document type:
Article
Affiliation country: