Tumor-derived exosomal miR-3157-3p promotes angiogenesis, vascular permeability and metastasis by targeting TIMP/KLF2 in non-small cell lung cancer.
Cell Death Dis
; 12(9): 840, 2021 09 08.
Article
in En
| MEDLINE
| ID: mdl-34497265
ABSTRACT
Metastasis is the main cause of death in patients with advanced lung cancer. The exosomes released by cancer cells create tumor microenvironment, and then accelerate tumor metastasis. Cancer-derived exosomes are considered to be the main driving force for metastasis niche formation at foreign sites, but the mechanism in Non-small cell lung carcinoma (NSCLC) is unclear. In metastatic NSCLC patients, the expression level of miR-3157-3p in circulating exosomes was significantly higher than that of non-metastatic NSCLC patients. Here, we found that miR-3157-3p can be transferred from NSCLC cells to vascular endothelial cells through exosomes. Our work indicates that exosome miR-3157-3p is involved in the formation of pre-metastatic niche formation before tumor metastasis and may be used as a blood-based biomarker for NSCLC metastasis. Exosome miR-3157-3p has regulated the expression of VEGF/MMP2/MMP9 and occludin in endothelial cells by targeting TIMP/KLF2, thereby promoted angiogenesis and increased vascular permeability. In addition, exosome miR-3157-3p promoted the metastasis of NSCLC in vivo.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Capillary Permeability
/
Carcinoma, Non-Small-Cell Lung
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Tissue Inhibitor of Metalloproteinase-2
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MicroRNAs
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Kruppel-Like Transcription Factors
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Exosomes
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Lung Neoplasms
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Neovascularization, Pathologic
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Cell Death Dis
Year:
2021
Document type:
Article
Affiliation country:
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
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UK
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UNITED KINGDOM