Memory destabilization during reconsolidation: a consequence of homeostatic plasticity?
Learn Mem
; 28(10): 371-389, 2021 10.
Article
in En
| MEDLINE
| ID: mdl-34526382
ABSTRACT
Remembering is not a static process When retrieved, a memory can be destabilized and become prone to modifications. This phenomenon has been demonstrated in a number of brain regions, but the neuronal mechanisms that rule memory destabilization and its boundary conditions remain elusive. Using two distinct computational models that combine Hebbian plasticity and synaptic downscaling, we show that homeostatic plasticity can function as a destabilization mechanism, accounting for behavioral results of protein synthesis inhibition upon reactivation with different re-exposure times. Furthermore, by performing systematic reviews, we identify a series of overlapping molecular mechanisms between memory destabilization and synaptic downscaling, although direct experimental links between both phenomena remain scarce. In light of these results, we propose a theoretical framework where memory destabilization can emerge as an epiphenomenon of homeostatic adaptations prompted by memory retrieval.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Memory Consolidation
/
Memory
Language:
En
Journal:
Learn Mem
Journal subject:
NEUROLOGIA
Year:
2021
Document type:
Article
Affiliation country: