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Inhibiting BCKDK in triple negative breast cancer suppresses protein translation, impairs mitochondrial function, and potentiates doxorubicin cytotoxicity.
Biswas, Dipsikha; Slade, Logan; Duffley, Luke; Mueller, Neil; Dao, Khoi Thien; Mercer, Angella; Pakkiriswami, Shanmugasundaram; El Hiani, Yassine; Kienesberger, Petra C; Pulinilkunnil, Thomas.
Affiliation
  • Biswas D; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada.
  • Slade L; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada.
  • Duffley L; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada.
  • Mueller N; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada.
  • Dao KT; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada.
  • Mercer A; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada.
  • Pakkiriswami S; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada.
  • El Hiani Y; Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Kienesberger PC; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada.
  • Pulinilkunnil T; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada. tpulinil@dal.ca.
Cell Death Discov ; 7(1): 241, 2021 Sep 15.
Article in En | MEDLINE | ID: mdl-34526485
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Cell Death Discov Year: 2021 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Cell Death Discov Year: 2021 Document type: Article Affiliation country: