The comparative epidemiology and outcomes of hospitalized patients treated with SGLT2 or DPP4 inhibitors.
J Diabetes Complications
; 35(12): 108052, 2021 12.
Article
in En
| MEDLINE
| ID: mdl-34600824
ABSTRACT
OBJECTIVE:
To compare the outcomes of sodium glucose linked cotransporter 2 inhibitors (SGLT2i) and dipeptidyl peptidase 4 inhibitors (DPP4i) in hospitalized patients. RESEARCH DESIGN ANDMETHODS:
Electronic medical records-based cohort study. Identification of patients with type 2 diabetes and treatment with SGLT2i (n = 466) or DPP4i (n = 1541). Outcomes compared between those who received SGLT2i and those who received DPP4i. The primaryoutcome:
adjusted percentage of blood glycemia within 4-10 mmol/L.RESULTS:
After adjustment, SGLT2i use had a statistically equivalent percentage of glycemia within range (coefficient 4.55, 95% CI -3.23 to 12.32, p = 0.25) or <4 mmol/L (coefficient -0.17, 95% CI -0.71 to 3.72, p = 0.54). There were no significant differences in hospital length of stay (p = 0.22), complications, (p = 0.11) or mortality (p = 0.57). When measured, ketone levels were higher in the SGLT2i group on admission, but lower on days 3, 4 and 5 (p < 0.001 for interaction). Bicarbonate levels were not statistically different between groups. Finally, 54% of patients whose SGLT2i was ceased during admission, were discharged home without it.CONCLUSION:
Among inpatients with type 2 diabetes, SGLT2i use was associated with equivalent within-target glycaemia and no significant increase in hypoglycemia, ketonemia, or lower bicarbonate levels. These hypothesis-generating findings support further investigation of SGLT2i therapy in inpatients.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Diabetes Mellitus, Type 2
/
Dipeptidyl-Peptidase IV Inhibitors
/
Sodium-Glucose Transporter 2 Inhibitors
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Oceania
Language:
En
Journal:
J Diabetes Complications
Journal subject:
ENDOCRINOLOGIA
Year:
2021
Document type:
Article
Affiliation country: