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A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction.
Kaptein, Suzanne J F; Goethals, Olivia; Kiemel, Dominik; Marchand, Arnaud; Kesteleyn, Bart; Bonfanti, Jean-François; Bardiot, Dorothée; Stoops, Bart; Jonckers, Tim H M; Dallmeier, Kai; Geluykens, Peggy; Thys, Kim; Crabbe, Marjolein; Chatel-Chaix, Laurent; Münster, Max; Querat, Gilles; Touret, Franck; de Lamballerie, Xavier; Raboisson, Pierre; Simmen, Kenny; Chaltin, Patrick; Bartenschlager, Ralf; Van Loock, Marnix; Neyts, Johan.
Affiliation
  • Kaptein SJF; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
  • Goethals O; Janssen Global Public Health, Janssen Pharmaceutica, Beerse, Belgium.
  • Kiemel D; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.
  • Marchand A; Cistim Leuven, Leuven, Belgium.
  • Kesteleyn B; Janssen Research & Development, Janssen Pharmaceutica, Beerse, Belgium.
  • Bonfanti JF; Janssen Infectious Diseases Discovery, Janssen-Cilag, Val de Reuil, France.
  • Bardiot D; Galapagos, Romainville, France.
  • Stoops B; Cistim Leuven, Leuven, Belgium.
  • Jonckers THM; Janssen Research & Development, Janssen Pharmaceutica, Beerse, Belgium.
  • Dallmeier K; Janssen Research & Development, Janssen Pharmaceutica, Beerse, Belgium.
  • Geluykens P; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
  • Thys K; Janssen Research & Development, Janssen Pharmaceutica, Beerse, Belgium.
  • Crabbe M; Charles River Beerse, Discovery, Beerse, Belgium.
  • Chatel-Chaix L; Janssen Research & Development, Janssen Pharmaceutica, Beerse, Belgium.
  • Münster M; Janssen Research & Development, Janssen Pharmaceutica, Beerse, Belgium.
  • Querat G; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.
  • Touret F; Institut National de la Recherche Scientifique, Centre Armand-Frappier Santé Biotechnologie, Quebec, Quebec, Canada.
  • de Lamballerie X; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.
  • Raboisson P; Unité des Virus Émergents (UVE), Aix-Marseille Univ, IRD 190 Inserm 1207, IHU Méditerranée Infection, Marseille, France.
  • Simmen K; Unité des Virus Émergents (UVE), Aix-Marseille Univ, IRD 190 Inserm 1207, IHU Méditerranée Infection, Marseille, France.
  • Chaltin P; Unité des Virus Émergents (UVE), Aix-Marseille Univ, IRD 190 Inserm 1207, IHU Méditerranée Infection, Marseille, France.
  • Bartenschlager R; Janssen Research & Development, Janssen Pharmaceutica, Beerse, Belgium.
  • Van Loock M; Aligos, Leuven, Belgium.
  • Neyts J; Janssen Research & Development, Janssen Pharmaceutica, Beerse, Belgium.
Nature ; 598(7881): 504-509, 2021 10.
Article in En | MEDLINE | ID: mdl-34616043
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Viral Nonstructural Proteins / Dengue / Dengue Virus / Membrane Proteins Limits: Animals Language: En Journal: Nature Year: 2021 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Viral Nonstructural Proteins / Dengue / Dengue Virus / Membrane Proteins Limits: Animals Language: En Journal: Nature Year: 2021 Document type: Article Affiliation country: Country of publication: