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ABCB1 and ABCG2 limit brain penetration and, together with CYP3A4, total plasma exposure of abemaciclib and its active metabolites.
Martínez-Chávez, Alejandra; Loos, Nancy H C; Lebre, Maria C; Tibben, Matthijs M; Rosing, Hilde; Beijnen, Jos H; Schinkel, Alfred H.
Affiliation
  • Martínez-Chávez A; Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • Loos NHC; Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • Lebre MC; Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • Tibben MM; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • Rosing H; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • Beijnen JH; Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences,
  • Schinkel AH; Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. Electronic address: a.schinkel@nki.nl.
Pharmacol Res ; 178: 105954, 2022 04.
Article in En | MEDLINE | ID: mdl-34700018
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzimidazoles / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Cytochrome P-450 CYP3A / ATP Binding Cassette Transporter, Subfamily G, Member 2 / Aminopyridines / Neoplasm Proteins Limits: Animals / Humans Language: En Journal: Pharmacol Res Journal subject: FARMACOLOGIA Year: 2022 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzimidazoles / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Cytochrome P-450 CYP3A / ATP Binding Cassette Transporter, Subfamily G, Member 2 / Aminopyridines / Neoplasm Proteins Limits: Animals / Humans Language: En Journal: Pharmacol Res Journal subject: FARMACOLOGIA Year: 2022 Document type: Article Affiliation country: Country of publication: