Bacterial phospholipases C with dual activity: phosphatidylcholinesterase and sphingomyelinase.
FEBS Open Bio
; 11(12): 3262-3275, 2021 12.
Article
in En
| MEDLINE
| ID: mdl-34709730
ABSTRACT
Bacterial phospholipases and sphingomyelinases are lipolytic esterases that are structurally and evolutionarily heterogeneous. These enzymes play crucial roles as virulence factors in several human and animal infectious diseases. Some bacterial phospholipases C (PLCs) have both phosphatidylcholinesterase and sphingomyelinase C activities. Among them, Listeria monocytogenes PlcB, Clostridium perfringens PLC, and Pseudomonas aeruginosa PlcH are the most deeply understood. In silico predictions of substrates docking with these three bacterial enzymes provide evidence that they interact with different substrates at the same active site. This review discusses structural aspects, substrate specificity, and the mechanism of action of those bacterial enzymes on target cells and animal infection models to shed light on their roles in pathogenesis.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Type C Phospholipases
/
Sphingomyelin Phosphodiesterase
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
FEBS Open Bio
Year:
2021
Document type:
Article
Affiliation country: