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Adolescent Binge Drinking Is Associated With Accelerated Decline of Gray Matter Volume.
Infante, M A; Eberson, S C; Zhang, Y; Brumback, T; Brown, S A; Colrain, I M; Baker, F C; Clark, D B; De Bellis, M D; Goldston, D; Nagel, B J; Nooner, K B; Zhao, Q; Pohl, K M; Sullivan, E V; Pfefferbaum, A; Tapert, S F; Thompson, W K.
Affiliation
  • Infante MA; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
  • Eberson SC; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
  • Zhang Y; Division of Biostatistics, Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, USA.
  • Brumback T; Population Neuroscience and Genetics Lab, University of California, San Diego, USA.
  • Brown SA; Department of Psychological Science, Northern Kentucky University, Kentucky, USA.
  • Colrain IM; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
  • Baker FC; Department of Psychology, University of California, San Diego, La Jolla, CA, USA.
  • Clark DB; Center for Health Sciences, SRI International, Menlo Park, CA, USA.
  • De Bellis MD; Center for Health Sciences, SRI International, Menlo Park, CA, USA.
  • Goldston D; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
  • Nagel BJ; Department of Psychiatry & Behavioral Sciences, Duke University, Durham, NC, USA.
  • Nooner KB; Department of Psychiatry & Behavioral Sciences, Duke University, Durham, NC, USA.
  • Zhao Q; Departments of Psychiatry and Behavioral Neuroscience, Oregon Health & Sciences University, Portland, OR, USA.
  • Pohl KM; Department of Psychology, University of North Carolina Wilmington, Wilmington, NC, USA.
  • Sullivan EV; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
  • Pfefferbaum A; Center for Health Sciences, SRI International, Menlo Park, CA, USA.
  • Tapert SF; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
  • Thompson WK; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Cereb Cortex ; 32(12): 2611-2620, 2022 06 07.
Article in En | MEDLINE | ID: mdl-34729592
ABSTRACT
The age- and time-dependent effects of binge drinking on adolescent brain development have not been well characterized even though binge drinking is a health crisis among adolescents. The impact of binge drinking on gray matter volume (GMV) development was examined using 5 waves of longitudinal data from the National Consortium on Alcohol and NeuroDevelopment in Adolescence study. Binge drinkers (n = 166) were compared with non-binge drinkers (n = 82 after matching on potential confounders). Number of binge drinking episodes in the past year was linked to decreased GMVs in bilateral Desikan-Killiany cortical parcellations (26 of 34 with P < 0.05/34) with the strongest effects observed in frontal regions. Interactions of binge drinking episodes and baseline age demonstrated stronger effects in younger participants. Statistical models sensitive to number of binge episodes and their temporal proximity to brain volumes provided the best fits. Consistent with prior research, results of this study highlight the negative effects of binge drinking on the developing brain. Our results present novel findings that cortical GMV decreases were greater in closer proximity to binge drinking episodes in a dose-response manner. This relation suggests a causal effect and raises the possibility that normal growth trajectories may be reinstated with alcohol abstinence.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Binge Drinking / Gray Matter Type of study: Prognostic_studies Limits: Adolescent / Humans Language: En Journal: Cereb Cortex Journal subject: CEREBRO Year: 2022 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Binge Drinking / Gray Matter Type of study: Prognostic_studies Limits: Adolescent / Humans Language: En Journal: Cereb Cortex Journal subject: CEREBRO Year: 2022 Document type: Article Affiliation country: