The use of carbamazepine to expedite the metabolism of a long-acting aripiprazole injection.
J Clin Pharm Ther
; 47(4): 562-566, 2022 Apr.
Article
in En
| MEDLINE
| ID: mdl-34750842
ABSTRACT
WHAT IS KNOWN AND OBJECTIVE:
Long-acting injectable (LAI) antipsychotics are an integral part of mental health treatment. Modifying an LAI regimen poses several challenges because of the extended half-life of the drug. CASESUMMARY:
An acutely psychotic patient with schizoaffective disorder received aripiprazole lauroxil without resolution of symptoms. She was started on a previously successful regimen of oral fluphenazine. Due to continued psychosis, oral carbamazepine was initiated to expedite the LAI's metabolism allowing subsequent doses of fluphenazine to impart activity. WHAT IS NEW ANDCONCLUSION:
Potent cytochrome enzyme inducers may help in transitioning patients from LAI antipsychotics to other therapies.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Schizophrenia
/
Antipsychotic Agents
Limits:
Female
/
Humans
Language:
En
Journal:
J Clin Pharm Ther
Journal subject:
FARMACIA
/
TERAPEUTICA
Year:
2022
Document type:
Article
Affiliation country: