Influence of inter-electrode distance on subthalamic nucleus local field potential recordings in Parkinson's disease.
Clin Neurophysiol
; 133: 29-38, 2022 01.
Article
in En
| MEDLINE
| ID: mdl-34794045
ABSTRACT
OBJECTIVES:
To evaluate spectra and their correlations with clinical symptoms of local field potentials (LFP) acquired from wide- and close-spaced contacts (i.e. between contacts 0-3 or LFP03, and contacts 1-2 or LFP12 respectively) on the same DBS electrode within the subthalamus (STN) in Parkinson's disease (PD), before and after levodopa administration.METHODS:
LFP12 and LFP03 were recorded from 20 PD patients. We evaluated oscillatory power, local and switched phase-amplitude coupling (l- and Sw-PAC) and correlation with motor symptoms (UPDRSIII).RESULTS:
Before levodopa, both LFP03 and LFP12 power in the α band inversely correlated with UPDRSIII. Differences between contacts were found in the low-frequency bands power. After levodopa, differences in UPDRSIII were associated to changes in LFP03 low-ß and LFP12 HFO (high frequency oscillations, 250-350 Hz) power, while a modulation of the low-ß power and an increased ß-LFO (low frequency oscillations, 15-45 Hz) PAC was found only for LFP12.CONCLUSION:
This study reveals differences in spectral pattern between LFP12 and LFP03 before and after levodopa administration, as well as different correlations with PD motor symptoms.SIGNIFICANCE:
Differences between LFP12 and LFP03 may offer an opportunity for optimizing adaptive deep brain stimulation (aDBS) protocols for PD. LFP12 can be used to detect ß-HFO coupling and ß power (i.e. bradykinesia), while LFP03 are optimal for low frequency oscillations (dyskinesias).Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parkinson Disease
/
Subthalamic Nucleus
/
Membrane Potentials
Type of study:
Guideline
Limits:
Adult
/
Aged
/
Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Clin Neurophysiol
Journal subject:
NEUROLOGIA
/
PSICOFISIOLOGIA
Year:
2022
Document type:
Article
Affiliation country: