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Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease.
Sugiyama, Michael G; Cui, Haotian; Redka, Dar'ya S; Karimzadeh, Mehran; Rujas, Edurne; Maan, Hassaan; Hayat, Sikander; Cheung, Kyle; Misra, Rahul; McPhee, Joseph B; Viirre, Russell D; Haller, Andrew; Botelho, Roberto J; Karshafian, Raffi; Sabatinos, Sarah A; Fairn, Gregory D; Madani Tonekaboni, Seyed Ali; Windemuth, Andreas; Julien, Jean-Philippe; Shahani, Vijay; MacKinnon, Stephen S; Wang, Bo; Antonescu, Costin N.
Affiliation
  • Sugiyama MG; Department of Chemistry and Biology, Ryerson University, Toronto, ON, Canada.
  • Cui H; Department of Computer Science, University of Toronto, Toronto, ON, Canada.
  • Redka DS; Vector Institute, Toronto, ON, Canada.
  • Karimzadeh M; Cyclica Inc., Toronto, ON, Canada.
  • Rujas E; Vector Institute, Toronto, ON, Canada.
  • Maan H; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
  • Hayat S; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.
  • Cheung K; Biofisika Institute (CSIC, UPV/EHU) and Department of Biochemistry and Molecular Biology, University of the Basque Country (UPV/EHU), Bilbao, Spain.
  • Misra R; Vector Institute, Toronto, ON, Canada.
  • McPhee JB; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • Viirre RD; Peter Munk Cardiac Centre, University Health Centre, Toronto, ON, Canada.
  • Haller A; Precision Cardiology Laboratory, Bayer US LLC, Cambridge, MA, USA.
  • Botelho RJ; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.
  • Karshafian R; Department of Chemistry and Biology, Ryerson University, Toronto, ON, Canada.
  • Sabatinos SA; Graduate Program in Molecular Science, Ryerson University, Toronto, ON, Canada.
  • Fairn GD; Department of Chemistry and Biology, Ryerson University, Toronto, ON, Canada.
  • Madani Tonekaboni SA; Department of Chemistry and Biology, Ryerson University, Toronto, ON, Canada.
  • Windemuth A; Graduate Program in Molecular Science, Ryerson University, Toronto, ON, Canada.
  • Julien JP; Department of Chemistry and Biology, Ryerson University, Toronto, ON, Canada.
  • Shahani V; Graduate Program in Molecular Science, Ryerson University, Toronto, ON, Canada.
  • MacKinnon SS; Phoenox Pharma, Toronto, ON, Canada.
  • Wang B; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
  • Antonescu CN; Department of Chemistry and Biology, Ryerson University, Toronto, ON, Canada.
Sci Rep ; 11(1): 23315, 2021 12 02.
Article in En | MEDLINE | ID: mdl-34857794
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Coronavirus / Drug Repositioning / Drug Development Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Sci Rep Year: 2021 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Coronavirus / Drug Repositioning / Drug Development Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Sci Rep Year: 2021 Document type: Article Affiliation country: