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Small molecules with tetrahydroquinoline-containing Povarov scaffolds as inhibitors disrupting the Protein-RNA interaction of LIN28-let-7.
Goebel, Georg L; Hohnen, Lisa; Borgelt, Lydia; Hommen, Pascal; Qiu, Xiaqiu; Lightfoot, Helen; Wu, Peng.
Affiliation
  • Goebel GL; Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund, 44227, Germany; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund, 44227, Germany; Faculty of Chemistry and Chemical Biology, TU Dortmund, Otto-Hahn Strasse 6, Dortmund, 44227, Germ
  • Hohnen L; Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund, 44227, Germany; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund, 44227, Germany; Faculty of Chemistry and Biochemistry, Ruhr-University Bochum, Universitätstr. 150, Bochum, 44780,
  • Borgelt L; Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund, 44227, Germany; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund, 44227, Germany; Faculty of Chemistry and Chemical Biology, TU Dortmund, Otto-Hahn Strasse 6, Dortmund, 44227, Germ
  • Hommen P; Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund, 44227, Germany; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund, 44227, Germany; Faculty of Chemistry and Chemical Biology, TU Dortmund, Otto-Hahn Strasse 6, Dortmund, 44227, Germ
  • Qiu X; Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund, 44227, Germany; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund, 44227, Germany; Faculty of Chemistry and Chemical Biology, TU Dortmund, Otto-Hahn Strasse 6, Dortmund, 44227, Germ
  • Lightfoot H; Safety & Mechanistic Pharmacology, Clinical Pharmacology and Safety Sciences, AstraZeneca, Cambridge, UK.
  • Wu P; Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Dortmund, 44227, Germany; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund, 44227, Germany. Electronic address: peng.wu@mpi-dortmund.mpg.de.
Eur J Med Chem ; 228: 114014, 2022 Jan 15.
Article in En | MEDLINE | ID: mdl-34883291
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / RNA / RNA-Binding Proteins / Small Molecule Libraries / Antineoplastic Agents Limits: Humans Language: En Journal: Eur J Med Chem Year: 2022 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / RNA / RNA-Binding Proteins / Small Molecule Libraries / Antineoplastic Agents Limits: Humans Language: En Journal: Eur J Med Chem Year: 2022 Document type: Article Country of publication: