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Maternal Phthalates Exposure and Blood Pressure during and after Pregnancy in the PROGRESS Study.
Wu, Haotian; Kupsco, Allison; Just, Allan; Calafat, Antonia M; Oken, Emily; Braun, Joseph M; Sanders, Alison P; Mercado-Garcia, Adriana; Cantoral, Alejandra; Pantic, Ivan; Téllez-Rojo, Martha M; Wright, Robert O; Baccarelli, Andrea A; Deierlein, Andrea L.
Affiliation
  • Wu H; Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA.
  • Kupsco A; Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA.
  • Just A; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Calafat AM; National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Oken E; Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.
  • Braun JM; Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island, USA.
  • Sanders AP; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Mercado-Garcia A; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Cantoral A; Center for Nutrition and Health Research, National Institute of Public Health, Ministry of Health, Cuernavaca, Morelos, Mexico.
  • Pantic I; Center for Nutrition and Health Research, National Institute of Public Health, Ministry of Health, Cuernavaca, Morelos, Mexico.
  • Téllez-Rojo MM; Department of Developmental Neurobiology, National Institute of Perinatology, Mexico City, Mexico.
  • Wright RO; Center for Nutrition and Health Research, National Institute of Public Health, Ministry of Health, Cuernavaca, Morelos, Mexico.
  • Baccarelli AA; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Deierlein AL; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Environ Health Perspect ; 129(12): 127007, 2021 12.
Article in En | MEDLINE | ID: mdl-34935432
ABSTRACT

BACKGROUND:

Phthalate exposure is ubiquitous and may affect biological pathways related to regulators of blood pressure. Given the profound changes in vasculature during pregnancy, pregnant women may be particularly susceptible to the potential effects of phthalates on blood pressure.

OBJECTIVES:

We examined associations of phthalate exposure during pregnancy with maternal blood pressure trajectories from mid-pregnancy through 72 months postpartum.

METHODS:

Women with singleton pregnancies delivering a live birth in Mexico City were enrolled during the second trimester (n=892). Spot urine samples from the second and third trimesters were analyzed for 15 phthalate metabolites. Blood pressure and covariate data were collected over nine visits through 72 months postpartum. We used linear, logistic, and linear mixed models; latent class growth models (LCGMs); and Bayesian kernel machine regression to estimate the relationship of urinary phthalate biomarkers with maternal blood pressure.

RESULTS:

As a joint mixture, phthalate biomarker concentrations during pregnancy were associated with higher blood pressure rise during mid-to-late gestation. With respect to individual biomarkers, second trimester concentrations of monobenzyl phthalate (MBzP) and di(2-ethylhexyl) phthalate biomarkersDEHP) were associated with higher third trimester blood pressure. Two trajectory classes were identified by LCGM, characterized by increasing blood pressure through 72 months postpartum ("increase-increase") or decreased blood pressure through 18 months postpartum with a gradual increase thereafter ("decrease-increase"). Increasing exposure to phthalate mixtures during pregnancy was associated with higher odds of being in the increase-increase class. Similar associations were observed for mono-2-ethyl-5-carboxypentyl terephthalate (MECPTP) and dibutyl phthalate (ΣDBP) biomarkers. When specific time periods were examined, we observed specific temporal relationships were observed for ΣDEHP, MECPTP, MBzP, and ΣDBP.

DISCUSSION:

In our cohort of pregnant women from Mexico City, exposure to phthalates and phthalate biomarkers was associated with higher blood pressure during late pregnancy, as well as with long-term changes in blood pressure trajectories. https//doi.org/10.1289/EHP8562.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phthalic Acids / Environmental Pollutants Type of study: Prognostic_studies Limits: Female / Humans / Pregnancy Language: En Journal: Environ Health Perspect Year: 2021 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phthalic Acids / Environmental Pollutants Type of study: Prognostic_studies Limits: Female / Humans / Pregnancy Language: En Journal: Environ Health Perspect Year: 2021 Document type: Article Affiliation country: