The beneficial effect of synbiotics consumption on Alzheimer's disease mouse model via reducing local and systemic inflammation.
IUBMB Life
; 74(8): 748-753, 2022 08.
Article
in En
| MEDLINE
| ID: mdl-34962691
ABSTRACT
Alzheimer's disease (AD) is a neurodegenerative disease that impairs multiple memory domains without an effective prevention or treatment approach. Amyloid plaque-induced neuroinflammation exacerbates neurodegeneration and cognitive impairment in AD. To reduce neuroinflammation, we applied prebiotics or synbiotics to modulate the gut-brain axis in the AD mouse model. AD-like deficits were reduced in mice treated with synbiotics, suggesting that dietary modulation of the gut-brain axis is a potential approach to delay AD progression.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Neurodegenerative Diseases
/
Synbiotics
/
Alzheimer Disease
Limits:
Animals
Language:
En
Journal:
IUBMB Life
Journal subject:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Year:
2022
Document type:
Article
Affiliation country: