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In vivo availability of the cytokine IL-7 constrains the survival and homeostasis of peripheral iNKT cells.
Park, Joo-Young; Won, Hee Yeun; DiPalma, Devon T; Kim, Hye Kyung; Kim, Tae-Hyoun; Li, Can; Sato, Noriko; Hong, Changwan; Abraham, Ninan; Gress, Ronald E; Park, Jung-Hyun.
Affiliation
  • Park JY; Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Building 10, Room 5B17, 10 Center Drive, Bethesda, MD 20892, USA; Department of Oral and Maxillofacial Surgery, Seoul National University School of Dentistry, Seoul National University Dental Hospital, 101 Da
  • Won HY; Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Building 10, Room 5B17, 10 Center Drive, Bethesda, MD 20892, USA.
  • DiPalma DT; Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Building 10, Room 5B17, 10 Center Drive, Bethesda, MD 20892, USA.
  • Kim HK; Experimental Transplantation Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Kim TH; Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Building 10, Room 5B17, 10 Center Drive, Bethesda, MD 20892, USA.
  • Li C; Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Building 10, Room 5B17, 10 Center Drive, Bethesda, MD 20892, USA.
  • Sato N; Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Hong C; Department of Anatomy, Pusan National University School of Medicine, Yangsan 626-870, South Korea.
  • Abraham N; Department of Microbiology and Immunology, and Department of Zoology, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
  • Gress RE; Experimental Transplantation Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Park JH; Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Building 10, Room 5B17, 10 Center Drive, Bethesda, MD 20892, USA. Electronic address: Parkhy@mail.nih.gov.
Cell Rep ; 38(2): 110219, 2022 01 11.
Article in En | MEDLINE | ID: mdl-35021100
ABSTRACT
Understanding the homeostatic mechanism of invariant natural killer T (iNKT) cells is a critical issue in iNKT cell biology. Because interleukin (IL)-15 is required for the thymic generation of iNKT cells, IL-15 has also been considered necessary for the homeostasis of peripheral iNKT cells. Here, we delineated the in vivo cytokine requirement for iNKT cells, and we came to the surprising conclusion that IL-7, not IL-15, is the homeostatic cytokine for iNKT cells. Employing a series of experimental mouse models where the availability of IL-7 or IL-15 was manipulated in peripheral tissues, either by genetic tools or by adult thymectomy and cytokine pump installation, we demonstrate that the abundance of IL-7, and not IL-15, limits the size of the peripheral iNKT cell pool. These results redefine the cytokine requirement for iNKT cells and indicate competition for IL-7 between iNKT and conventional αß T cells.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Differentiation / Interleukin-7 / Natural Killer T-Cells Limits: Animals Language: En Journal: Cell Rep Year: 2022 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Differentiation / Interleukin-7 / Natural Killer T-Cells Limits: Animals Language: En Journal: Cell Rep Year: 2022 Document type: Article