Your browser doesn't support javascript.
loading
Tofacitinib Inhibits Leukocyte Trafficking Across the Intestinal Endothelial Barrier in a Specific Cohort of Ulcerative Colitis Patients.
Massimino, Luca; Spanò, Salvatore; Lamparelli, Luigi Antonio; Fuggetta, Davide; Peyrin-Biroulet, Laurent; Sileri, Pierpaolo; Danese, Silvio; D'Alessio, Silvia; Ungaro, Federica.
Affiliation
  • Massimino L; Department of Gastroenterology and Digestive Endoscopy, IRCCS Ospedale San Raffaele Hospital, Milan, Italy.
  • Spanò S; Department of Gastroenterology and Digestive Endoscopy, IRCCS Ospedale San Raffaele Hospital, Milan, Italy.
  • Lamparelli LA; Laboratory of Gastrointestinal Immunopathology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
  • Fuggetta D; Laboratory of Gastrointestinal Immunopathology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
  • Peyrin-Biroulet L; INSERM NGERE, University of Lorraine, Vandoeuvre-les-Nancy, France.
  • Sileri P; Nancy University Hospital, Vandoeuvre-les-Nancy, France.
  • Danese S; Gastrointestinal Surgery Unit, IRCCS Ospedale San Raffaele, MilanItaly.
  • D'Alessio S; Department of Gastroenterology and Digestive Endoscopy, IRCCS Ospedale San Raffaele Hospital, Milan, Italy.
  • Ungaro F; Università Vita-Salute San Raffaele, Milan, Italy.
Inflamm Bowel Dis ; 28(6): 971-976, 2022 06 03.
Article in En | MEDLINE | ID: mdl-35032171
The JAK/STAT inhibitor tofacitinib, recently approved for the treatment of ulcerative colitis, is found to modulate the intestinal endothelial barrier functions in directing the leukocyte adhesion and transmigration in ulcerative colitis patients displaying high levels of endothelial STAT3/STAT6 phosphorylation.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colitis, Ulcerative Limits: Humans Language: En Journal: Inflamm Bowel Dis Journal subject: GASTROENTEROLOGIA Year: 2022 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colitis, Ulcerative Limits: Humans Language: En Journal: Inflamm Bowel Dis Journal subject: GASTROENTEROLOGIA Year: 2022 Document type: Article Affiliation country: Country of publication: