Pedal to the Metal: The Homogeneous Catalysis of the Native Chemical Ligation Reaction.
Chemistry
; 28(16): e202104229, 2022 Mar 16.
Article
in En
| MEDLINE
| ID: mdl-35048443
ABSTRACT
The native chemical ligation reaction of peptide thioesters with cysteinyl peptides is a pivotal chemical process in the production of native or modified peptides and proteins, and well beyond in the preparation of various biomolecule analogs and materials. To benefit from this reaction at its fullest and to access all the possible applications, the experimentalist needs to know the factors affecting its rate and how to control it. This concept article presents the fundamental principles underlying the rate of the native chemical ligation and its homogeneous catalysis by nucleophiles. It has been prepared to serve as a quick guide in the search for an appropriate catalyst.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptides
/
Sulfhydryl Compounds
Language:
En
Journal:
Chemistry
Journal subject:
QUIMICA
Year:
2022
Document type:
Article
Affiliation country: