COVID-19-induced pulmonary sarcoid: A case report and review of the literature.
Clin Imaging
; 83: 152-158, 2022 Mar.
Article
in En
| MEDLINE
| ID: mdl-35051738
ABSTRACT
BACKGROUND:
The COVID-19 pandemic has resulted in dramatic loss of life worldwide, but as the large number of acutely ill patients subsides, the emerging group of "COVID-19 long-haulers" present a clinical challenge. Studies have shown that many of these patients suffer long-term pulmonary disease related to residual fibrosis. Prior studies have shown that while many patients have non-specific findings of fibrotic-like changes, others develop specific patterns of interstitial lung disease. CASE REPORT Here, we present the first case of a patient developing pulmonary sarcoidosis one year after critical illness from COVID-19. He developed numerous non-necrotizing and well-formed granulomas in mediastinal lymph nodes and pulmonary nodules, compatible radiographically and pathologically with sarcoid.CONCLUSIONS:
While the pathophysiology of sarcoid is incompletely understood, inflammation is mediated through the dysregulation of a number of different cytokines (IFNγ, IL-2, IL-12, IL-17, IL-22). This case provides valuable clues for better understanding of the shared pathophysiology of cytokine dysregulation seen in COVID-19 and other interstitial lung diseases such as sarcoidosis.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sarcoidosis
/
Sarcoidosis, Pulmonary
/
COVID-19
Limits:
Humans
/
Male
Language:
En
Journal:
Clin Imaging
Journal subject:
DIAGNOSTICO POR IMAGEM
Year:
2022
Document type:
Article