MNCD: A New Tool for Classifying Parkinson's Disease in Daily Clinical Practice.
Diagnostics (Basel)
; 12(1)2021 Dec 28.
Article
in En
| MEDLINE
| ID: mdl-35054222
ABSTRACT
Background and objective:
Parkinson's disease (PD) is a clinically heterogeneous disorder in which the symptoms and prognosis can be very different among patients. We propose a new simple classification to identify key symptoms and staging in PD. Patients andMethods:
Sixteen movement disorders specialists from Spain participated in this project. The classification was consensually approved after a discussion and review process from June to October 2021. The TNM classification and the National Institutes of Health Stroke Scale (NIHSS) were considered as models in the design.Results:
The classification was named MNCD and included 4 major axes (1) motor symptoms; (2) non-motor symptoms; (3) cognition; (4) dependency for activities of daily living (ADL). Motor axis included 4 sub-axes (1) motor fluctuations; (2) dyskinesia; (3) axial symptoms; (4) tremor. Four other sub-axes were included in the non-motor axis (1) neuropsychiatric symptoms; (2) autonomic dysfunction; (3) sleep disturbances and fatigue; (4) pain and sensory disorders. According to the MNCD, 5 stages were considered, from stage 1 (no disabling motor or non-motor symptoms with normal cognition and independency for ADL) to 5 (dementia and dependency for basic ADL).Conclusions:
A new simple classification of PD is proposed. The MNCD classification includes 4 major axes and 5 stages to identify key symptoms and monitor the evolution of the disease in patients with PD. It is necessary to apply this proof of concept in a properly designed study.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Diagnostics (Basel)
Year:
2021
Document type:
Article
Affiliation country: