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Atazanavir Is a Competitive Inhibitor of SARS-CoV-2 Mpro, Impairing Variants Replication In Vitro and In Vivo.
Chaves, Otávio Augusto; Sacramento, Carolina Q; Ferreira, André C; Mattos, Mayara; Fintelman-Rodrigues, Natalia; Temerozo, Jairo R; Vazquez, Leonardo; Pinto, Douglas Pereira; da Silveira, Gabriel P E; da Fonseca, Laís Bastos; Pereira, Heliana Martins; Carlos, Aluana Santana; d'Avila, Joana C; Viola, João P B; Monteiro, Robson Q; Bozza, Patrícia T; Castro-Faria-Neto, Hugo Caire; Souza, Thiago Moreno L.
Affiliation
  • Chaves OA; Laboratory of Immunopharmacology, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro 21040-360, Brazil.
  • Sacramento CQ; Center for Technological Development in Health (CDTS), National Institute for Science and Technology on Innovation on Neglected Diseases Neglected Populations (INCT/IDNP), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro 21040-900, Brazil.
  • Ferreira AC; Laboratory of Immunopharmacology, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro 21040-360, Brazil.
  • Mattos M; Center for Technological Development in Health (CDTS), National Institute for Science and Technology on Innovation on Neglected Diseases Neglected Populations (INCT/IDNP), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro 21040-900, Brazil.
  • Fintelman-Rodrigues N; Laboratory of Immunopharmacology, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro 21040-360, Brazil.
  • Temerozo JR; Center for Technological Development in Health (CDTS), National Institute for Science and Technology on Innovation on Neglected Diseases Neglected Populations (INCT/IDNP), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro 21040-900, Brazil.
  • Vazquez L; Preclinical Research Laboratory, Universidade Iguaçu-UNIG, Nova Iguacu 26260-045, Brazil.
  • Pinto DP; Laboratory of Immunopharmacology, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro 21040-360, Brazil.
  • da Silveira GPE; Center for Technological Development in Health (CDTS), National Institute for Science and Technology on Innovation on Neglected Diseases Neglected Populations (INCT/IDNP), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro 21040-900, Brazil.
  • da Fonseca LB; Laboratory of Immunopharmacology, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro 21040-360, Brazil.
  • Pereira HM; Center for Technological Development in Health (CDTS), National Institute for Science and Technology on Innovation on Neglected Diseases Neglected Populations (INCT/IDNP), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro 21040-900, Brazil.
  • Carlos AS; Laboratory on Thymus Research, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro 21040-900, Brazil.
  • d'Avila JC; National Institute for Science and Technology on Neuroimmunomodulation (INCT/NIM), Rio de Janeiro 21040-900, Brazil.
  • Viola JPB; Laboratory of Immunopharmacology, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro 21040-360, Brazil.
  • Monteiro RQ; Laboratory of Pharmacokinetics, Vice Presidency of Research, and Innovation in Health, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro 21040-900, Brazil.
  • Bozza PT; Laboratory of Pharmacokinetics, Vice Presidency of Research, and Innovation in Health, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro 21040-900, Brazil.
  • Castro-Faria-Neto HC; Laboratory of Pharmacokinetics, Vice Presidency of Research, and Innovation in Health, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro 21040-900, Brazil.
  • Souza TML; Laboratory of Pharmacokinetics, Vice Presidency of Research, and Innovation in Health, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro 21040-900, Brazil.
Pharmaceuticals (Basel) ; 15(1)2021 Dec 24.
Article in En | MEDLINE | ID: mdl-35056078
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Pharmaceuticals (Basel) Year: 2021 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Pharmaceuticals (Basel) Year: 2021 Document type: Article Affiliation country: