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Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration: protocol for a systematic review with individual participant data meta-analysis of behavioural interventions for the prevention of early childhood obesity.
Hunter, Kylie E; Johnson, Brittany J; Askie, Lisa; Golley, Rebecca K; Baur, Louise A; Marschner, Ian C; Taylor, Rachael W; Wolfenden, Luke; Wood, Charles T; Mihrshahi, Seema; Hayes, Alison J; Rissel, Chris; Robledo, Kristy P; O'Connor, Denise A; Espinoza, David; Staub, Lukas P; Chadwick, Paul; Taki, Sarah; Barba, Angie; Libesman, Sol; Aberoumand, Mason; Smith, Wendy A; Sue-See, Michelle; Hesketh, Kylie D; Thomson, Jessica L; Bryant, Maria; Paul, Ian M; Verbestel, Vera; Stough, Cathleen Odar; Wen, Li Ming; Larsen, Junilla K; O'Reilly, Sharleen L; Wasser, Heather M; Savage, Jennifer S; Ong, Ken K; Salvy, Sarah-Jeanne; Messito, Mary Jo; Gross, Rachel S; Karssen, Levie T; Rasmussen, Finn E; Campbell, Karen; Linares, Ana Maria; Øverby, Nina Cecilie; Palacios, Cristina; Joshipura, Kaumudi J; González Acero, Carolina; Lakshman, Rajalakshmi; Thompson, Amanda L; Maffeis, Claudio; Oken, Emily.
Affiliation
  • Hunter KE; NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia kylie.hunter@sydney.edu.au.
  • Johnson BJ; Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, South Australia, Australia.
  • Askie L; NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Golley RK; Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, South Australia, Australia.
  • Baur LA; Children's Hospital Westmead Clinical School, The University of Sydney, Westmead, New South Wales, Australia.
  • Marschner IC; NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Taylor RW; Department of Medicine, University of Otago, Dunedin, New Zealand.
  • Wolfenden L; School of Medicine and Public Health, The University of Newcastle, Callaghan, New South Wales, Australia.
  • Wood CT; School of Medicine, Duke University, Durham, North Carolina, USA.
  • Mihrshahi S; Department of Health Systems and Populations, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.
  • Hayes AJ; School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
  • Rissel C; School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
  • Robledo KP; NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • O'Connor DA; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.
  • Espinoza D; Monash Department of Clinical Epidemiology, Cabrini Institute, Malvern, Victoria, Australia.
  • Staub LP; NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Chadwick P; NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Taki S; Centre For Behaviour Change, University College London, London, UK.
  • Barba A; School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
  • Libesman S; Population Health Research and Evaluation Hub, Sydney Local Health District, Camperdown, New South Wales, Australia.
  • Aberoumand M; NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Smith WA; NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Sue-See M; NHMRC Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Hesketh KD; Canterbury Community Health Centre, Sydney Local Health District, Campsie, New South Wales, Australia.
  • Thomson JL; Consumer Representative, Sydney, New South Wales, Australia.
  • Bryant M; Consumer Representative, Sydney, New South Wales, Australia.
  • Paul IM; Institute for Physical Activity and Nutrition, Deakin University, Geelong, Victoria, Australia.
  • Verbestel V; Agricultural Research Service, USDA, Stoneville, Mississippi, USA.
  • Stough CO; Department of Health Sciences and the Hull York Medical School, University of York, York, UK.
  • Wen LM; Penn State College of Medicine, Hershey, Pennsylvania, USA.
  • Larsen JK; Department of Rehabilitation Sciences, Ghent University, Ghent, Belgium.
  • O'Reilly SL; Department of Psychology, University of Cincinnati, Cincinnati, Ohio, USA.
  • Wasser HM; School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
  • Savage JS; Population Health Research and Evaluation Hub, Sydney Local Health District, Camperdown, New South Wales, Australia.
  • Ong KK; Behavioural Science Institute, Radboud Universiteit, Nijmegen, The Netherlands.
  • Salvy SJ; School of Agriculture and Food Science, University College Dublin, Dublin, Ireland.
  • Messito MJ; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Gross RS; Department of Nutritional Sciences & Center for Childhood Obesity Research, Pennsylvania State University, University Park, Pennsylvania, USA.
  • Karssen LT; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
  • Rasmussen FE; Research Center for Health Equity, Cedars-Sinai Medical Center, West Hollywood, California, USA.
  • Campbell K; Grossman School of Medicine, New York University, New York, New York, USA.
  • Linares AM; Grossman School of Medicine, New York University, New York, New York, USA.
  • Øverby NC; Behavioural Science Institute, Radboud Universiteit, Nijmegen, The Netherlands.
  • Palacios C; Department of Global Public Health, Karolinska Institute, Stockholm, Sweden.
  • Joshipura KJ; Institute for Physical Activity and Nutrition, Deakin University, Geelong, Victoria, Australia.
  • González Acero C; College of Nursing, University of Kentucky, Lexington, Kentucky, USA.
  • Lakshman R; Faculty of Health and Sport Sciences, Department of Nutrition and Public Health, University of Agder, Kristiansand, Vest-Agder, Norway.
  • Thompson AL; Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, Miami, Florida, USA.
  • Maffeis C; Department of Epidemiology, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.
  • Oken E; Center for Clinical Research and Health Promotion, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, USA.
BMJ Open ; 12(1): e048166, 2022 Jan 20.
Article in En | MEDLINE | ID: mdl-35058256
ABSTRACT

INTRODUCTION:

Behavioural interventions in early life appear to show some effect in reducing childhood overweight and obesity. However, uncertainty remains regarding their overall effectiveness, and whether effectiveness differs among key subgroups. These evidence gaps have prompted an increase in very early childhood obesity prevention trials worldwide. Combining the individual participant data (IPD) from these trials will enhance statistical power to determine overall effectiveness and enable examination of individual and trial-level subgroups. We present a protocol for a systematic review with IPD meta-analysis to evaluate the effectiveness of obesity prevention interventions commencing antenatally or in the first year after birth, and to explore whether there are differential effects among key subgroups. METHODS AND

ANALYSIS:

Systematic searches of Medline, Embase, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycInfo and trial registries for all ongoing and completed randomised controlled trials evaluating behavioural interventions for the prevention of early childhood obesity have been completed up to March 2021 and will be updated annually to include additional trials. Eligible trialists will be asked to share their IPD; if unavailable, aggregate data will be used where possible. An IPD meta-analysis and a nested prospective meta-analysis will be performed using methodologies recommended by the Cochrane Collaboration. The primary outcome will be body mass index z-score at age 24±6 months using WHO Growth Standards, and effect differences will be explored among prespecified individual and trial-level subgroups. Secondary outcomes include other child weight-related measures, infant feeding, dietary intake, physical activity, sedentary behaviours, sleep, parenting measures and adverse events. ETHICS AND DISSEMINATION Approved by The University of Sydney Human Research Ethics Committee (2020/273) and Flinders University Social and Behavioural Research Ethics Committee (HREC CIA2133-1). Results will be relevant to clinicians, child health services, researchers, policy-makers and families, and will be disseminated via publications, presentations and media releases. PROSPERO REGISTRATION NUMBER CRD42020177408.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pediatric Obesity Type of study: Clinical_trials / Guideline / Observational_studies / Systematic_reviews Aspects: Ethics Limits: Child / Child, preschool / Humans / Infant Language: En Journal: BMJ Open Year: 2022 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pediatric Obesity Type of study: Clinical_trials / Guideline / Observational_studies / Systematic_reviews Aspects: Ethics Limits: Child / Child, preschool / Humans / Infant Language: En Journal: BMJ Open Year: 2022 Document type: Article Affiliation country: