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Magnetic Responsive Release of Nitric Oxide from an MOF-Derived Fe3O4@PLGA Microsphere for the Treatment of Bacteria-Infected Cutaneous Wound.
Chung, Chieh-Wei; Liao, Bo-Wen; Huang, Shu-Wei; Chiou, Show-Jen; Chang, Cheng-Han; Lin, Sheng-Ju; Chen, Bo-Hao; Liu, Wei-Ling; Hu, Shang-Hsiu; Chuang, Yu-Chun; Lin, Chia-Her; Hsu, I-Jui; Cheng, Chao-Min; Huang, Chieh-Cheng; Lu, Tsai-Te.
Affiliation
  • Chung CW; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan.
  • Liao BW; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan.
  • Huang SW; Department of Emergency Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
  • Chiou SJ; Department of Applied Chemistry, National Chiayi University, Chiayi 60004, Taiwan.
  • Chang CH; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 30013, Taiwan.
  • Lin SJ; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan.
  • Chen BH; National Synchrotron Radiation Research Center, Hsinchu 30076, Taiwan.
  • Liu WL; Department of Chemistry, National Taiwan Normal University, Taipei 11677, Taiwan.
  • Hu SH; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 30013, Taiwan.
  • Chuang YC; National Synchrotron Radiation Research Center, Hsinchu 30076, Taiwan.
  • Lin CH; Department of Chemistry, National Taiwan Normal University, Taipei 11677, Taiwan.
  • Hsu IJ; Department of Molecular Science and Engineering, Research and Development Center of Smart Textile Technology, National Taipei University of Technology, Taipei 10608, Taiwan.
  • Cheng CM; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan.
  • Huang CC; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan.
  • Lu TT; Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan.
ACS Appl Mater Interfaces ; 14(5): 6343-6357, 2022 Feb 09.
Article in En | MEDLINE | ID: mdl-35080366
Nitric oxide (NO) is an essential endogenous signaling molecule regulating multifaceted physiological functions in the (cardio)vascular, neuronal, and immune systems. Due to the short half-life and location-/concentration-dependent physiological function of NO, translational application of NO as a novel therapeutic approach, however, awaits a strategy for spatiotemporal control on the delivery of NO. Inspired by the magnetic hyperthermia and magneto-triggered drug release featured by Fe3O4 conjugates, in this study, we aim to develop a magnetic responsive NO-release material (MagNORM) featuring dual NO-release phases, namely, burst and steady release, for the selective activation of NO-related physiology and treatment of bacteria-infected cutaneous wound. After conjugation of NO-delivery [Fe(µ-S-thioglycerol)(NO)2]2 with a metal-organic framework (MOF)-derived porous Fe3O4@C, encapsulation of obtained conjugates within the thermo-responsive poly(lactic-co-glycolic acid) (PLGA) microsphere completes the assembly of MagNORM. Through continuous/pulsatile/no application of the alternating magnetic field (AMF) to MagNORM, moreover, burst/intermittent/slow release of NO from MagNORM demonstrates the AMF as an ON/OFF switch for temporal control on the delivery of NO. Under continuous application of the AMF, in particular, burst release of NO from MagNORM triggers an effective anti-bacterial activity against both Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli). In addition to the magneto-triggered bactericidal effect of MagNORM against E. coli-infected cutaneous wound in mice, of importance, steady release of NO from MagNORM without the AMF promotes the subsequent collagen formation and wound healing in mice.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ferrosoferric Oxide / Magnetic Fields / Metal-Organic Frameworks / Polylactic Acid-Polyglycolic Acid Copolymer / Microspheres / Nitric Oxide Limits: Animals Language: En Journal: ACS Appl Mater Interfaces Journal subject: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Year: 2022 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ferrosoferric Oxide / Magnetic Fields / Metal-Organic Frameworks / Polylactic Acid-Polyglycolic Acid Copolymer / Microspheres / Nitric Oxide Limits: Animals Language: En Journal: ACS Appl Mater Interfaces Journal subject: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Year: 2022 Document type: Article Affiliation country: Country of publication: