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Homozygous ALS-linked FUS P525L mutations cell- autonomously perturb transcriptome profile and chemoreceptor signaling in human iPSC microglia.
Kerk, Sze Yen; Bai, Yu; Smith, Janell; Lalgudi, Pranav; Hunt, Charleen; Kuno, Junko; Nuara, John; Yang, Tao; Lanza, Kathryn; Chan, Newton; Coppola, Angel; Tang, Qian; Espert, Jennifer; Jones, Henderson; Fannell, Casey; Zambrowicz, Brian; Chiao, Eric.
Affiliation
  • Kerk SY; Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA. Electronic address: john.kerk@regeneron.com.
  • Bai Y; Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA.
  • Smith J; Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA.
  • Lalgudi P; Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA.
  • Hunt C; Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA.
  • Kuno J; Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA.
  • Nuara J; Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA.
  • Yang T; Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA.
  • Lanza K; Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA.
  • Chan N; Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA.
  • Coppola A; Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA.
  • Tang Q; Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA.
  • Espert J; Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA.
  • Jones H; Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA.
  • Fannell C; Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA.
  • Zambrowicz B; Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA.
  • Chiao E; Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA. Electronic address: eric.chiao@regeneron.com.
Stem Cell Reports ; 17(3): 678-692, 2022 03 08.
Article in En | MEDLINE | ID: mdl-35120624
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA-Binding Protein FUS / Induced Pluripotent Stem Cells / Amyotrophic Lateral Sclerosis Limits: Humans Language: En Journal: Stem Cell Reports Year: 2022 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA-Binding Protein FUS / Induced Pluripotent Stem Cells / Amyotrophic Lateral Sclerosis Limits: Humans Language: En Journal: Stem Cell Reports Year: 2022 Document type: Article