Limonoids from the fruits of Chisocheton lasiocarpus (Meliaceae).
J Asian Nat Prod Res
; 25(1): 36-43, 2023 Jan.
Article
in En
| MEDLINE
| ID: mdl-35128999
ABSTRACT
Two new azadirone-type limonoids, namely lasiocarpine A (1) and lasiocarpine B (2) were isolated from the fruit of Chisocheton lasiocarpus along with three known limonoids (3-5). UV, IR, one- and two- dimensional NMR, and mass spectrometry were used to determine the chemical structure of the isolated compounds. Furthermore, their cytotoxic activity against breast cancer cell line MCF-7 was evaluated using PrestoBlue reagent. From these compounds, lasiocarpine A (1) showed the strongest activity with an IC50 value of 43.38 µM.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Meliaceae
/
Limonins
/
Antineoplastic Agents
Language:
En
Journal:
J Asian Nat Prod Res
Journal subject:
BOTANICA
/
QUIMICA
Year:
2023
Document type:
Article
Affiliation country: