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Combining p53 mRNA nanotherapy with immune checkpoint blockade reprograms the immune microenvironment for effective cancer therapy.
Xiao, Yuling; Chen, Jiang; Zhou, Hui; Zeng, Xiaodong; Ruan, Zhiping; Pu, Zhangya; Jiang, Xingya; Matsui, Aya; Zhu, Lingling; Amoozgar, Zohreh; Chen, Dean Shuailin; Han, Xiangfei; Duda, Dan G; Shi, Jinjun.
Affiliation
  • Xiao Y; Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Chen J; Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Zhou H; Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, China.
  • Zeng X; Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Ruan Z; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, 430071, Wuhan, China.
  • Pu Z; Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Jiang X; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, 430071, Wuhan, China.
  • Matsui A; Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Zhu L; Department of Medical Oncology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Amoozgar Z; Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Chen DS; Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Han X; Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Duda DG; Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Shi J; Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Nat Commun ; 13(1): 758, 2022 02 09.
Article in En | MEDLINE | ID: mdl-35140208

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Messenger / Tumor Suppressor Protein p53 / Tumor Microenvironment / Immune Checkpoint Inhibitors Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Messenger / Tumor Suppressor Protein p53 / Tumor Microenvironment / Immune Checkpoint Inhibitors Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Document type: Article Affiliation country: